Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid (Journal article)

Toliopoulos, I. K./ Simos, Y. V./ Daskalou, T. A./ Verginadis,, II/ Evangelou, A. M./ Karkabounas, S. C.

Platelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3 x 10(-3) M concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Ascorbic Acid/*pharmacology,Blood Platelets/drug effects/immunology,Cell Survival/drug effects/immunology,Dose-Response Relationship, Drug,Flow Cytometry,Humans,Immunomodulation/*drug effects,K562 Cells,Killer Cells, Natural/*drug effects/immunology,Leukocytes, Mononuclear/drug effects,Platelet Aggregation/*drug effects,Platelet Aggregation Inhibitors/*pharmacology,Platelet Glycoprotein GPIIb-IIIa Complex/biosynthesis,Thromboxane B2/antagonists & inhibitors/biosynthesis
ISSN: 0019-5189
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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