Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid (Journal article)

Toliopoulos, I. K./ Simos, Y. V./ Daskalou, T. A./ Verginadis,, II/ Evangelou, A. M./ Karkabounas, S. C.

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dc.contributor.authorToliopoulos, I. K.en
dc.contributor.authorSimos, Y. V.en
dc.contributor.authorDaskalou, T. A.en
dc.contributor.authorVerginadis,, IIen
dc.contributor.authorEvangelou, A. M.en
dc.contributor.authorKarkabounas, S. C.en
dc.date.accessioned2015-11-24T19:09:48Z-
dc.date.available2015-11-24T19:09:48Z-
dc.identifier.issn0019-5189-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/20750-
dc.rightsDefault Licence-
dc.subjectAscorbic Acid/*pharmacologyen
dc.subjectBlood Platelets/drug effects/immunologyen
dc.subjectCell Survival/drug effects/immunologyen
dc.subjectDose-Response Relationship, Drugen
dc.subjectFlow Cytometryen
dc.subjectHumansen
dc.subjectImmunomodulation/*drug effectsen
dc.subjectK562 Cellsen
dc.subjectKiller Cells, Natural/*drug effects/immunologyen
dc.subjectLeukocytes, Mononuclear/drug effectsen
dc.subjectPlatelet Aggregation/*drug effectsen
dc.subjectPlatelet Aggregation Inhibitors/*pharmacologyen
dc.subjectPlatelet Glycoprotein GPIIb-IIIa Complex/biosynthesisen
dc.subjectThromboxane B2/antagonists & inhibitors/biosynthesisen
dc.titleInhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic aciden
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondaryhttp://www.ncbi.nlm.nih.gov/pubmed/22403863-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.publicationDate2011-
heal.abstractPlatelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3 x 10(-3) M concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.en
heal.journalNameIndian J Exp Biolen
heal.journalTypepeer-reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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