Inhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic acid (Journal article)

Toliopoulos, I. K./ Simos, Y. V./ Daskalou, T. A./ Verginadis,, II/ Evangelou, A. M./ Karkabounas, S. C.

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dc.contributor.authorToliopoulos, I. K.en
dc.contributor.authorSimos, Y. V.en
dc.contributor.authorDaskalou, T. A.en
dc.contributor.authorVerginadis,, IIen
dc.contributor.authorEvangelou, A. M.en
dc.contributor.authorKarkabounas, S. C.en
dc.rightsDefault Licence-
dc.subjectAscorbic Acid/*pharmacologyen
dc.subjectBlood Platelets/drug effects/immunologyen
dc.subjectCell Survival/drug effects/immunologyen
dc.subjectDose-Response Relationship, Drugen
dc.subjectFlow Cytometryen
dc.subjectImmunomodulation/*drug effectsen
dc.subjectK562 Cellsen
dc.subjectKiller Cells, Natural/*drug effects/immunologyen
dc.subjectLeukocytes, Mononuclear/drug effectsen
dc.subjectPlatelet Aggregation/*drug effectsen
dc.subjectPlatelet Aggregation Inhibitors/*pharmacologyen
dc.subjectPlatelet Glycoprotein GPIIb-IIIa Complex/biosynthesisen
dc.subjectThromboxane B2/antagonists & inhibitors/biosynthesisen
dc.titleInhibition of platelet aggregation and immunomodulation of NK lymphocytes by administration of ascorbic aciden
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικήςel
heal.abstractPlatelets aggregation around migrating tumor cells offers protection against the cytotoxic activity of the natural killers cells (NKC). The ascorbic acid in 3 x 10(-3) M concentration completely inhibited platelet aggregation, decreased thromboxane B2 levels, and inhibited the expression of platelet membranic receptor GpIIb/IIIa in non stimulated platelets, and increased the NKC cytotoxicity in an average rate of 105, 61, and 285% in the NKC/targets cells ratios 12.5:1, 25:1 and 50:1 respectively. The results suggest the role of ascorbic acid in increasing the susceptibility of tumor cells to NKC; the ascorbic acid could be used as part of a multidrug therapy to treat diseases which up to now have been treated only through chemotherapy.en
heal.journalNameIndian J Exp Biolen
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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