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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Katsenos, S. | en |
| dc.contributor.author | Nikolopoulou, M. | en |
| dc.contributor.author | Konstantinidis, A. K. | en |
| dc.contributor.author | Gartzonika, C. | en |
| dc.contributor.author | Gogali, A. | en |
| dc.contributor.author | Margelis, I. | en |
| dc.contributor.author | Tatsioni, A. | en |
| dc.contributor.author | Mavridis, A. | en |
| dc.contributor.author | Constantopoulos, S. H. | en |
| dc.contributor.author | Daskalopoulos, G. | en |
| dc.date.accessioned | 2015-11-24T19:09:28Z | - |
| dc.date.available | 2015-11-24T19:09:28Z | - |
| dc.identifier.issn | 1815-7920 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/20705 | - |
| dc.rights | Default Licence | - |
| dc.subject | Adjuvants, Immunologic/administration & dosage | en |
| dc.subject | Adolescent | en |
| dc.subject | Adult | en |
| dc.subject | BCG Vaccine/*administration & dosage | en |
| dc.subject | Cross-Sectional Studies | en |
| dc.subject | Female | en |
| dc.subject | Greece | en |
| dc.subject | Humans | en |
| dc.subject | Interferon-gamma/*diagnostic use | en |
| dc.subject | Male | en |
| dc.subject | Military Personnel | en |
| dc.subject | Tuberculin Test/*methods | en |
| dc.subject | Tuberculosis/*diagnosis/immunology | en |
| dc.subject | Young Adult | en |
| dc.title | Interferon-gamma release assay clarifies the effect of bacille Calmette-Guerin vaccination in Greek army recruits | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.secondary | http://www.ncbi.nlm.nih.gov/pubmed/20392346 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής | el |
| heal.publicationDate | 2010 | - |
| heal.abstract | OBJECTIVE: To compare the most recent commercial interferon-gamma release assay (IGRA), the QuantiFERON-TB Gold In-Tube (QFT-GIT), with the tuberculin skin test (TST) in Greek army recruits who were bacille Calmette-Guerin (BCG) vaccinated during childhood and had no history of tuberculosis (TB) exposure. METHOD: We conducted a cross-sectional comparison study of 1750 young army recruits. TST was performed on all participants, while QFT-GIT was performed in all subjects with TST > 0 mm and in 18 TST-negative controls (TST = 0 mm). RESULTS: Among the study subjects, 5.4% (96/1750) had TST indurations of >or=10 mm, and 3.4% (59/1750) had indurations of >or=15 mm. Among subjects with a positive TST, 11.4% (11/96) tested positive on QFT-GIT. All those with QFT-GIT positivity had TST indurations of >or=15 mm, and none of those with TST indurations of 10-14 mm were positive by QFT-GIT. The overall agreement between TST and QFT-GIT was poor (kappa = 0.02). CONCLUSION: We found a significant discordance between TST and QFT-GIT in BCG-vaccinated Greek army recruits consistent with previous studies showing that BCG received after infancy produces false-positive TST reactions. Our findings underline the need for a two-step approach in diagnosing latent TB infection in all BCG-vaccinated individuals: initial TST screening, followed by an IGRA to confirm TST positivity. | en |
| heal.journalName | Int J Tuberc Lung Dis | en |
| heal.journalType | peer-reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά) - ΙΑΤ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tatsioni-2010-interferon gamma release.pdf | 264.37 kB | Adobe PDF | View/Open Request a copy |
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