Pulmonary involvement in systemic sclerosis. Association with anti-Scl 70 antibody and digital pitting (Journal article)

Manoussakis, M. N./ Constantopoulos, S. H./ Gharavi, A. E./ Moutsopoulos, H. M.


The association of clinical and serologic features of 34 patients with systemic sclerosis was examined. Anti-Scl 70 antibody was found to identify patients with abnormal pulmonary function, particularly impaired diffusion (p less than 0.005), as well as patients with digital pitting scars (p less than 0.025). In addition, the presence of digital pitting scars correlated with impaired diffusion (p less than 0.005), suggesting that interstitial pulmonary disease in systemic sclerosis may, like digital pitting, be secondary to vascular pathology. Anticentromere antibody-positive patients were less likely to have abnormalities of pulmonary function (p less than 0.001).
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Autoantibodies/*immunology,Autoimmune Diseases/*immunology,Centromere/immunology,Female,Humans,Male,*Nuclear Proteins,Nucleoproteins/*immunology,Pulmonary Diffusing Capacity,Pulmonary Fibrosis/*etiology/immunology,Scleroderma, Systemic/*complications/immunology
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/18895
ISSN: 0012-3692
Link: http://www.ncbi.nlm.nih.gov/pubmed/3622029
http://chestjournal.chestpubs.org/content/92/3/509.full.pdf
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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