Shared epitopes and rheumatoid arthritis: disease associations in Greece and meta-analysis of Mediterranean European populations (Journal article)

Ioannidis, J. P./ Tarassi, K./ Papadopoulos, I. A./ Voulgari, P. V./ Boki, K. A./ Papasteriades, C. A./ Drosos, A. A.

OBJECTIVES: To assess the strength of the associations between HLA shared epitopes (SE) and rheumatoid arthritis (RA) susceptibility, articular disease severity, and extra-articular features in Mediterranean European populations. METHODS: One hundred and seventy-four Greek RA patients and 103 controls were evaluated. Data were then included in a meta-analysis of 9 studies of Mediterranean European populations (959 RA patients and 1,405 controls). RESULTS: In our study population, SE alleles were significantly more common in RA patients than in controls (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.4-4.3). Larsen radiologic score was predicted by SE and disease duration. SE did not increase the risk of any extra-articular manifestation. The meta-analysis showed a pooled OR of 3.7 (95% CI, 2.6-5.2) for susceptibility to RA conferred by SE (OR, 3.4 v 3.9 in Greek v non-Greek populations). CONCLUSIONS: SE determine articular destruction without increasing the risk of extra-articular manifestations. The immunogenetic associations of RA susceptibility are consistent, but their strength may depend on the SE prevalence in different ethnic groups.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Keywords: Adolescent,Adult,Aged,Arthritis, Rheumatoid/epidemiology/ genetics/physiopathology,Female,Genetic Predisposition to Disease,Greece/epidemiology,Histocompatibility Antigens Class II/ genetics,Humans,Male,Mediterranean Region/epidemiology,Middle Aged,Severity of Illness Index
ISSN: 0049-0172
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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