Radical therapy for muscle-infiltrating bladder cancer (cystectomy or radiotherapy): does age affect the final therapeutic benefit for the patient? (Journal article)

Kalogeras, D./ Lampri, E./ Goussia, A./ Bai, M./ Capizzello, A./ Tassiou, I./ Stavropoulos, N. E./ Tsekeris, P.

Purpose: To evaluate the therapeutic outcome of radical cystectomy and radical radio therapy in patients with T2N0M0 clinical stage bladder cancer in relation to their age. Patients and methods: Between 1995-2006, 119 patients with clinical stage T2N0M0 bladder cancer were treated with radical radiotherapy (group A) and were divided in 2 subgroups: > 70 years old(A1) and <= 70 years old (A2). Between 1998-2006, 26 patients with the same clinical stage were treated with radical cystectomy (group B) (> 70 years old/B1 subgroup and <= 70 years old/B2 subgroup). The following parameters were evaluated in both groups and subgroups: therapeutic outcome (overall survival/OS, local control, development of metastases) and tolerance (side effects and complications of each method). Kaplan-Meier method and log-rank test were used for statistical analyses. Results: All group B patients tolerated their treatment very well, without interruptions. The 3-year OS of groups A and B was 39 and 69%, respectively (p= 0.032). The 3-year OS of subgroups A I and A 2 was 37.3 and 43.3%, respectively (p= 0.085). In the cystectomy group B, 3-year OS of the subgroups was the same (B1: 68.6% and B2: 69.3%; p= 0.10). Local control rate for the subgroups A1, A2, B1, B2 was 43, 40, 90 and 84%, respectively. Distant metastatic rate was 14.1, 20, 7.6 and 7.4% for subgroups A1, A2, B1, B2, respectively. Conclusion: The results of both therapeutic methods in both age groups seem satisfactory. Very good tolerance was also observed. It seems that if a patient is not completely suitable for radical cystectomy or radical radiotherapy age should not be considered as an exclusion factor.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Keywords: age,bladder cancer,cystectomy,muscle-infiltrating,radiotherapy,survival,transitional-cell carcinoma,ileal conduit diversion,term-follow-up,neoadjuvant chemotherapy,survival,preservation,complications,metastases,radiation,prostate
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/17288
ISSN: 1107-0625
Link: <Go to ISI>://000259689200006
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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