Lipophilic Caffeic Acid Derivatives Protect Cells against H2O2-Induced DNA Damage by Chelating Intracellular Labile Iron (Journal article)

Kitsati, N./ Fokas, D./ Ouzouni, M. D./ Mantzaris, M. D./ Barbouti, A./ Galaris, D.

Naturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular "labile" iron. These results support the notion that numerous lipophilic iron chelating compounds, present abundantly in plant-derived diet components, may protect cells in conditions of oxidative stress and in this way be important contributors toward maintenance of human health.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικών
Keywords: oxidative stress,caffeic acid,cinnamic acid derivatives,DNA damage,labile iron,nf-kappa-b,hydrogen-peroxide,phenethyl ester,oxidative stress,phenolic-acids,in-vitro,antioxidant,apoptosis,pool,metabolism
ISSN: 0021-8561
Link: <Go to ISI>://000307487100015
Publisher: American Chemical Society
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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