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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/14120
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dc.contributor.authorKitsati, N.en
dc.contributor.authorFokas, D.en
dc.contributor.authorOuzouni, M. D.en
dc.contributor.authorMantzaris, M. D.en
dc.contributor.authorBarbouti, A.en
dc.contributor.authorGalaris, D.en
dc.date.accessioned2015-11-24T17:35:23Z-
dc.date.available2015-11-24T17:35:23Z-
dc.identifier.issn0021-8561-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/14120-
dc.rightsDefault Licence-
dc.subjectoxidative stressen
dc.subjectcaffeic aciden
dc.subjectcinnamic acid derivativesen
dc.subjectDNA damageen
dc.subjectlabile ironen
dc.subjectnf-kappa-ben
dc.subjecthydrogen-peroxideen
dc.subjectphenethyl esteren
dc.subjectoxidative stressen
dc.subjectphenolic-acidsen
dc.subjectin-vitroen
dc.subjectantioxidanten
dc.subjectapoptosisen
dc.subjectpoolen
dc.subjectmetabolismen
dc.titleLipophilic Caffeic Acid Derivatives Protect Cells against H2O2-Induced DNA Damage by Chelating Intracellular Labile Ironen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDoi 10.1021/Jf301237y-
heal.identifier.secondary<Go to ISI>://000307487100015-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Μηχανικών Επιστήμης Υλικώνel
heal.publicationDate2012-
heal.abstractNaturally occurring cinnamic acid derivatives are ubiquitously distributed in the plant kingdom, and it has been proposed that their consumption contributes to the maintenance of human health. However, the molecular mechanisms underlying their health keeping effects remain unknown. In the present investigation, we evaluated the capacity of several cinnamic acid derivatives (trans-cinnamic, p-coumaric, caffeic and ferulic acids, as well as caffeic acid-methyl and -propyl esters) to protect cells from oxidative stress-induced DNA damage. It was observed that effective protection was based on the ability of each compound to (i) reach the intracellular space and (ii) chelate intracellular "labile" iron. These results support the notion that numerous lipophilic iron chelating compounds, present abundantly in plant-derived diet components, may protect cells in conditions of oxidative stress and in this way be important contributors toward maintenance of human health.en
heal.publisherAmerican Chemical Societyen
heal.journalNameJ Agric Food Chemen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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