Effects of non-steroid anti-inflammatory drugs in membrane bilayers (Journal article)

Kyrikou, I./ Hadjikakou, S. K./ Kovala-Demertzi, D./ Viras, K./ Mavromoustakos, T.

The thermal effects of non-steroidal anti-inflammatory drugs (NSAIDs) meloxicam, tenoxicam, piroxicam and lornoxicam have been studied in dipalmitoylphosphatidylcholine (DPPC) membrane bilayers using neutral and acidic environments (pH 2.5). The strength of the perturbing effect of the drugs is summarized to a lowering of the main phase transition temperature and a broadening of the phase transition temperature as well as broadening or abolishment of the pretransition of DPPC bilayers. The thermal profiles in the two environments were very similar. Among the NSAIDs studied meloxicam showed the least perturbing effect. The differential scanning calorimetry results (DSC) in combination with molecular modeling studies point out that NSAIDs are characterized by amphoteric interactions and are extended between the polar and hydrophobic segments of lipid bilayers. The effects of NSAIDs in membrane bilayers were also investigated using Raman spectroscopy. Meloxicam showed a gauche:trans profile similar to DPPC bilayers while the other NSAIDs increased significantly the gauche:trans ratio. In conclusion, both techniques show that in spite of the close structural similarity of the NSAIDs studied, meloxicam appears to have the lowest membrane perturbing effects probably attributed to its highest lipophilicity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: nsaids,lipid bilayers,molecular modeling,differential scanning calorimetry,raman spectroscopy,differential scanning calorimetry,metal-complexes,lipid-bilayers,raman-spectra,dipalmitoylphosphatidylcholine,osteoarthritis,spectroscopy,transition,disorder,steroids
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/10568
ISSN: 0009-3084
Link: <Go to ISI>://000225678200002
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Kyrikou-2004-Effects of non-stero.pdf690.22 kBAdobe PDFView/Open    Request a copy

 Please use this identifier to cite or link to this item:
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.