Effects of non-steroid anti-inflammatory drugs in membrane bilayers (Journal article)

Kyrikou, I./ Hadjikakou, S. K./ Kovala-Demertzi, D./ Viras, K./ Mavromoustakos, T.


Full metadata record
DC FieldValueLanguage
dc.contributor.authorKyrikou, I.en
dc.contributor.authorHadjikakou, S. K.en
dc.contributor.authorKovala-Demertzi, D.en
dc.contributor.authorViras, K.en
dc.contributor.authorMavromoustakos, T.en
dc.date.accessioned2015-11-24T16:57:19Z-
dc.date.available2015-11-24T16:57:19Z-
dc.identifier.issn0009-3084-
dc.identifier.urihttp://olympias.lib.uoi.gr/jspui/handle/123456789/10568-
dc.rightsDefault Licence-
dc.subjectnsaidsen
dc.subjectlipid bilayersen
dc.subjectmolecular modelingen
dc.subjectdifferential scanning calorimetryen
dc.subjectraman spectroscopyen
dc.subjectdifferential scanning calorimetryen
dc.subjectmetal-complexesen
dc.subjectlipid-bilayersen
dc.subjectraman-spectraen
dc.subjectdipalmitoylphosphatidylcholineen
dc.subjectosteoarthritisen
dc.subjectspectroscopyen
dc.subjecttransitionen
dc.subjectdisorderen
dc.subjectsteroidsen
dc.titleEffects of non-steroid anti-inflammatory drugs in membrane bilayersen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.chemphyslip.2004.06.005-
heal.identifier.secondary<Go to ISI>://000225678200002-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0009308404001252/1-s2.0-S0009308404001252-main.pdf?_tid=5480dd8482df1378c0af33c90421fccd&acdnat=1333030215_13af80fead01d1ca850c0abc41e597cd-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2004-
heal.abstractThe thermal effects of non-steroidal anti-inflammatory drugs (NSAIDs) meloxicam, tenoxicam, piroxicam and lornoxicam have been studied in dipalmitoylphosphatidylcholine (DPPC) membrane bilayers using neutral and acidic environments (pH 2.5). The strength of the perturbing effect of the drugs is summarized to a lowering of the main phase transition temperature and a broadening of the phase transition temperature as well as broadening or abolishment of the pretransition of DPPC bilayers. The thermal profiles in the two environments were very similar. Among the NSAIDs studied meloxicam showed the least perturbing effect. The differential scanning calorimetry results (DSC) in combination with molecular modeling studies point out that NSAIDs are characterized by amphoteric interactions and are extended between the polar and hydrophobic segments of lipid bilayers. The effects of NSAIDs in membrane bilayers were also investigated using Raman spectroscopy. Meloxicam showed a gauche:trans profile similar to DPPC bilayers while the other NSAIDs increased significantly the gauche:trans ratio. In conclusion, both techniques show that in spite of the close structural similarity of the NSAIDs studied, meloxicam appears to have the lowest membrane perturbing effects probably attributed to its highest lipophilicity. (C) 2004 Elsevier Ireland Ltd. All rights reserved.en
heal.publisherElsevieren
heal.journalNameChemistry and Physics of Lipidsen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Kyrikou-2004-Effects of non-stero.pdf690.22 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/10568
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.