Development of a sensitive flow injection-chemiluminescence detection method for the indirect determination of propranolol (Journal article)

Tsogas, G. Z./ Stergiou, D. V./ Vlessidis, A. G./ Evmiridis, N. P.


A highly sensitive flow injection-chemiluminescence detection (FI-CL) method based on pyrogallol (Pg) chemiluminescentreagent (CL-reagent) oxidized by periodate for the determination of propranolol is presented. The presented method is an indirect CL detection method based on the CL emission generated during the oxidation of Pg with the excess of periodate that remains after oxidation of propranolol within the time period of 10 min. The obtained propranolol calibration curve is linear up to 1.0 mg(-1) with a sensitivity of -0.95 V mg(-1). At higher than 1.0 mg l(-1) propranolol concentrations the propranolol calibration curve is still linear up to 20.0 mg l(-1) with a sensitivity of -0.05 V mg(-1) 1. The detection limit is restricted from the noise level and at S/N = 3 was found to be 37.4 mu g l(-1) (3.74 ng) with R.S.D.% = 0.34 for seven replicate measurements. (c) 2004 Elsevier B.V. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: propranolol determination,chemiluminescence detection,flow injection analysis,pyrogallol,periodate,pharmaceutical-preparations,capillary electrophoresis,liquid-chromatography,mass-spectrometry,pyrogallol,oxidation,periodate,hcl
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/10380
ISSN: 0003-2670
Link: <Go to ISI>://000229648500019
http://ac.els-cdn.com/S0003267004016290/1-s2.0-S0003267004016290-main.pdf?_tid=cde0264c-356a-11e3-9e6d-00000aacb35f&acdnat=1381822038_e7e129de2c68c14f6d7b142c4307a10a
Publisher: Elsevier Masson
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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