Calreticulin Synthetic Peptide Analogs - Antipeptide Antibodies in Autoimmune Rheumatic Diseases (Journal article)

Routsias, J. G./ Tzioufas, A. G./ Sakarellos-Daitsiotis, M./ Sakarellos, C./ Moutsopoulos, H. M.

Autoantibodies in sera from patients with systemic lupus erythematosus (SLE) and onchocerciasis recognize calreticulin (CaR), a calcium-binding protein, as antigen. In this study we present the immunological properties of two synthetic peptides prepared to correspond to the 1-24 and 7-24 amino acid sequence of CaR. In contrast to information previously reported for the recombinant protein, the CaR-peptide analogues appeared immunoreactive to anti-Ro/SSA autoimmune sera. Human sera from patients with SLE, Sjogren's syndrome (SS), rheumatoid arthritis (RA), as well as mixed connective tissue disease (MCTD), demonstrated a positive autoimmune response (binding of antibodies), to the CaR-peptide analogues. These findings suggest that anti-calreticulin autoantibodies are not restricted to any disease specificity.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: calreticulin,ro/ssa,autoimmune rheumatic diseases,synthetic peptides,calcium-binding protein,ro/ss-a autoantigen,ro ribonucleoprotein,lupus-erythematosus,molecular-cloning,particle,sequence,heterogeneity,calregulin,component
ISSN: 0009-9104
Link: <Go to ISI>://A1993KP26700016
Publisher: Blackwell
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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