Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine (Journal article)

Xanthopoulou, M. N./ Hadjikakou, S. K./ Hadjiliadis, N./ Kourkoumelis, N./ Milaeva, E. R./ Gracheva, Y. A./ Tyurin, V. Y./ Verginadis, I./ Karkabounas, S./ Baril, M./ Butler, I. S.

The known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bu2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1-4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of complexes 2-4 was demonstrated.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: bioinorganic chemistry,complexes,organotin(iv) complexes,2-mercaptopyrimidine,lipoxygenases,antitumor activity,crystal-structure,linoleic-acid,derivatives,tin
ISSN: 1066-5285
Link: <Go to ISI>://000249952200016
Publisher: Springer
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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