Biological studies of organotin(IV) complexes with 2-mercaptopyrimidine (Journal article)

Xanthopoulou, M. N./ Hadjikakou, S. K./ Hadjiliadis, N./ Kourkoumelis, N./ Milaeva, E. R./ Gracheva, Y. A./ Tyurin, V. Y./ Verginadis, I./ Karkabounas, S./ Baril, M./ Butler, I. S.


The known organotin(IV) complexes with 2-mercaptopyrimidine (L) [Me2SnL2] (1), [Bu2SnL2] (2), [Ph2SnL2] (3), and [Ph3SnL] (4) were synthesized using a new approach. The effect of the synthesized compounds on peroxidation of fatty acids (oleic and linoleic) was studied. Complexes 1-4 promote the peroxidation of oleic acid. Their effect on the enzymatic peroxidation of linoleic acid with lipoxygenase was compared with that of cisplatin and in vitro cytoxicity against sarcoma cancer cells was determined. The antiproliferative effect of complexes 2-4 was demonstrated.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: bioinorganic chemistry,complexes,organotin(iv) complexes,2-mercaptopyrimidine,lipoxygenases,antitumor activity,crystal-structure,linoleic-acid,derivatives,tin
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/9982
ISSN: 1066-5285
Link: <Go to ISI>://000249952200016
http://www.springerlink.com/content/qm5825544418844m/fulltext.pdf
Publisher: Springer
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Xanthopoulou-2007-Biological studies o.pdf389.99 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/9982
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.