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https://olympias.lib.uoi.gr/jspui/handle/123456789/9969Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Kovala-Demertzi, D. | en |
| dc.contributor.author | Galani, A. | en |
| dc.contributor.author | Demertzis, M. A. | en |
| dc.contributor.author | Skoulika, S. | en |
| dc.contributor.author | Kotoglou, C. | en |
| dc.date.accessioned | 2015-11-24T16:53:05Z | - |
| dc.date.available | 2015-11-24T16:53:05Z | - |
| dc.identifier.issn | 0162-0134 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9969 | - |
| dc.rights | Default Licence | - |
| dc.subject | nsaids | en |
| dc.subject | tolfenamic | en |
| dc.subject | crystal structure | en |
| dc.subject | spectroscopic study | en |
| dc.subject | sod mimetic | en |
| dc.subject | metal-complexes | en |
| dc.subject | antiinflammatory properties | en |
| dc.subject | acid | en |
| dc.subject | diclofenac | en |
| dc.title | Binuclear copper(II) complexes of tolfenamic: synthesis, crystal structure, spectroscopy and superoxide dismutase activity | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.jinorgbio.2003.11.004 | - |
| heal.identifier.secondary | <Go to ISI>://000188711200018 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0162013403004410/1-s2.0-S0162013403004410-main.pdf?_tid=2a130c5fa8aa1e8ce0187e8622ce0995&acdnat=1333028827_8a54671ff3d9941a1d1f2789002e8531 | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2004 | - |
| heal.abstract | The synthesis and characterization of copper(II) complexes with a potent non-steroidal anti-inflammatory drug, tolfenamic acid, Htolf, with formula [Cu(tolf)(2)L](2) (where L is H2O or DMF, N,N-dimethylformamide) were investigated. The crystal-and molecular structure Of [Cu(tolf)(2)(DMF)](2) was reported. Crystallographic data are as follows: monoclinic system, space group P2(1)/n with cell constants a = 9.068(2) Angstrom, b = 14.514(3) Angstrom, c = 22.826(4) Angstrom, V = 2948.9(10) Angstrom(3) and Z = 2. The crystal structure consists of binuclear, quadruply bridged neutral molecule with a Cu-Cu bond length of 2.6075(19) Angstrom. The complex is self-assembled via C-H-pi intermolecular stacking interactions. Spectroscopic and electrochemical studies were reported. The superoxide dismutase activity is measured and compared with those of superoxide dismutase enzyme, SOD, the free ligand and related copper complexes with nonsteroidal anti-inflammatory drugs, NSAIDs. IC50 value was measured by the Fridovich test (1.97 +/- 0.17 muM), which showed that [Cu(tolf)(2)L](2) is a good superoxide scavenger. (C) 2003 Elsevier Inc. All rights reserved. | en |
| heal.journalName | J Inorg Biochem | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Kovala-Demertzi-2004-Binuclear copper(II).pdf | 352.13 kB | Adobe PDF | View/Open Request a copy |
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