Association of the inflammatory state in active juvenile rheumatoid arthritis with hypo-high-density lipoproteinemia and reduced lipoprotein-associated platelet-activating factor acetylhydrolase activity (Journal article)

Tselepis, A. D./ Elisaf, M./ Besis, S./ Karabina, S. A. P./ Chapman, M. J./ Siamopoulou, A.


Objective. To investigate the relationship between the quantitative and qualitative abnormalities of apolipoprotein B (Apo B)- and Apo A-I-containing lipoproteins and between lipoprotein-associated platelet-activating factor acetylhydrolase (PAF-AH) activity in patients with juvenile rheumatoid arthritis (JRA) as a function of the inflammatory state. Methods. Twenty-six JRA patients and 22 age- and sex-matched control subjects with normal lipid levels participated in the study. Fourteen patients had active disease, and 12 had inactive disease. Plasma lipoproteins were fractionated by gradient ultracentrifugation into 9 subfractions, and their chemical composition and mass were determined. The PAF-AH activity associated with lipoprotein subfractions and the activity in plasma were also measured. Results. Patients with active JRA had significantly lower plasma total cholesterol and high-density lipoprotein (HDL) cholesterol levels as compared with controls, due to the decrease in the mass of both the HDL2 and HDL3 subfractions. Patients with active JRA also had higher plasma triglyceride levels, mainly due to the higher triglyceride content of the very low-density lipoprotein plus the intermediate-density lipoprotein subfraction. The plasma PBF-AH activity in patients with active JRA was lower than that in controls, mainly due to the decrease in PAF-AH activity associated with the intermediate and dense low-density lipoprotein subclasses. The lipid abnormalities and the reduction in plasma PAF-AH activity were significantly correlated with plasma C-reactive protein levels and were not observed in patients with inactive JRA. Conclusion. This is the first study to show that patients with active JRA exhibit low levels of HDL2 and HDL3 and are deficient in plasma PAF-AH activity. These alterations suggest that active JRA is associated with partial loss of the antiinflammatory activity of plasma Apo B- and Apo A-I-containing lipoproteins.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: human-plasma,familial hypercholesterolemia,human-serum,ldl,cholesterol,degradation,oxidation,lipase,hypertriglyceridemia,hypocholesterolemia
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/9938
ISSN: 0004-3591
Link: <Go to ISI>://000078469000021
http://onlinelibrary.wiley.com/store/10.1002/1529-0131(199902)42:2<373::AID-ANR21>3.0.CO;2-3/asset/21_ftp.pdf?v=1&t=h0f8b0ry&s=b25595a47e45c77940dac0ce716843540fcb1658
Publisher: Lippincott Williams & Wilkins
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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