Application of chemometric assisted dispersive liquid-liquid microextraction to the determination of personal care products in natural waters (Journal article)

Panagiotou, A. N./ Sakkas, V. A./ Albanis, T. A.

A rapid and simple method for the determination of two phthalates and five polycyclic musks in water samples using dispersive liquid-liquid microextraction (DLLME) mated to chemometrics and coupled to GC-MS was developed. Volume of extraction (CCl(4)) and disperser solvent (MeOH), pH, ionic strength, extraction time, centrifugation time as well as centrifugation speed were optimized in a 2(7-4) Plackett-Burman design. The obtained significant factors were optimized by using a central composite design (CCD) and the quadratic model between the dependent and the independent variables was built. The optimum experimental conditions of the proposed method were: 250 mu L, carbon tetrachloride, 0.62 ml, methanol, 7.5 min centrifugation time, natural pH containing 0% (w/v) NaCl, while keeping centrifugation speed fixed at 4000 rpm. The calculated calibration curves gave high-level linearity for all target analytes with correlation coefficients ranging between 0.9970 and 0.9992. The repeatability and reproducibility of the proposed method, expressed as relative standard deviation, varied between 2.6% to 9.7% and 5.7% to 12.2%, respectively. The obtained LOD values were in the range of 8-63 ng L(-1). (C) 2009 Elsevier B.V. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: experimental design,response surface methodology,phthalic acid esters,polycyclic musks,electron-capture detection,solid-phase microextraction,chromatography-mass spectrometry,single-drop microextraction,flame photometric detection,polycyclic musk fragrances,gas-chromatography,waste-water,phthalate-esters,capillary-electrophoresis
ISSN: 0003-2670
Link: <Go to ISI>://000269652800001
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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