Application of a Picrolonate Ion-Selective Electrode to the Assay of Calcium and Piperazine in Pharmaceuticals and Serum (Journal article)

Veltsistas, P. G./ Prodromidis, M. I./ Karayannis, M. I.

The construction and some analytical applications of a liquid picrolonate (Picrl(-)) ion-selective electrode based on the tris(phenanthrolinato)iron(II) (ferroin) picrolonate salt, dissolved in 2-nitrotoluene, are described. The liquid membrane electrode exhibits a rapid and almost Nernstian response to picrolonate anions in the concentration range from 5 X 10(-2) to 5 X 10(-2) mol l(-1). The response is virtually unaffected by pH changes ih the range 3-10. Major interferents are picrates, 4-nitrophenolates, 3,5-dinitrosalicylates and 2,4-dinitrophenolates. In analytical applications direct potentiomctric methods for the determination of picrolonates and indirect methods for the determination of calcium and piperazine are described. calcium in the ranges 4-24 and 50-90 mg l(-1), under specified experimental conditions,can be determined with mean relative errors of 1.1 and 1.4%, respectively. The method is applicable to soluble samples, pharmaceuticals and industrial and real human serum. Piperazine in the ranges 1-10 and 13-20 mg can be determined with a mean relative error of 1.2% in soluble salts and pharmaceutical formulations, respectively. An accuracy of better than 1.5% and a reproducibility (relative standard deviation) of 0.1.% mere achieved in the analysis of pharmaceutical products.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: picrolonic acid,picrolonate liquid ion-selective electrode,calcium and piperazine determination,pharmaceuticals,serum
ISSN: 0003-2654
Link: <Go to ISI>://A1994NZ70100033
Publisher: Royal Society of Chemistry
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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