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  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ
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Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/9878
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dc.contributor.authorStanojkovic, T. P.en
dc.contributor.authorKovala-Demertzi, D.en
dc.contributor.authorPrimikyri, A.en
dc.contributor.authorGarcia-Santos, I.en
dc.contributor.authorCastineiras, A.en
dc.contributor.authorJuranic, Z.en
dc.contributor.authorDemertzis, M. A.en
dc.date.accessioned2015-11-24T16:52:24Z-
dc.date.available2015-11-24T16:52:24Z-
dc.identifier.issn0162-0134-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/9878-
dc.rightsDefault Licence-
dc.subjectzn(ii)en
dc.subjectcomplexesen
dc.subjectthiosemicarbazoneen
dc.subjectcrystal structureen
dc.subjectin vitro antitumor activityen
dc.subjectbiological evaluationen
dc.subjectrapid colorimetric assayen
dc.subjectantitumor-activityen
dc.subjectpalladium(ii) complexesen
dc.subjectplatinum(ii) complexesen
dc.subjectspectral propertiesen
dc.subjectmetal-complexesen
dc.subjectin-vitroen
dc.titleZinc(II) complexes of 2-acetyl pyridine 1-(4-fluorophenyl)-piperazinyl thiosemicarbazone: Synthesis, spectroscopic study and crystal structures - Potential anticancer drugsen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1016/j.jinorgbio.2009.12.021-
heal.identifier.secondary<Go to ISI>://000274921200014-
heal.identifier.secondaryhttp://ac.els-cdn.com/S0162013410000036/1-s2.0-S0162013410000036-main.pdf?_tid=44fdb8c46a09fc4b6915fc4606fc5026&acdnat=1333028971_e4cb8d8dd0d0be54a70edb0bb617b948-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.publicationDate2010-
heal.abstract2-Acetyl pyridine thiosemicarbazone containing an 1-(4-fluorophenyl)-piperazinyl ring incorporated at N(4)-position, HAcPipPheF (1) and the zinc(II) complexes [Zn(AcPipPheF)(2)] (2) and [Zn(OAc)(AcPipPheF)](2) (3) have been prepared and structurally characterized by means of vibrational and NMR ((1)H and (13)C) spectroscopy. The crystal structures of the compounds 1-3 have been determined by X-ray crystallography. The metal coordination geometry of [Zn(AcPipPheF)(2)] is described as distorted octahedral configuration in a trans-N-cis-N-cis-S configuration. In [Zn(OAc)(AcPipPheF)](2) one of the acetato group exhibits monoatomic bridge and the other bridges in a bidentate manner. The zinc(1) metal ion is coordinated in a distorted octahedral configuration while the metal coordination of Zn(2) is described as distorted square pyramidal. Biomedical studies revealed that, compounds 1-3 displayed potent anticancer activity. The antiproliferative activity of 1-3 was found to be considerably stronger than that of cis-platin. The IC(50) values range from 26 to 90 nM, against all cell lines tested, while for cis-platin the IC(50) values range from 2 to 17 mu M and for the zinc salt, ZnCl(2), the IC(50) values range from 81 to 93 mu M. The complex 3 shows the highest activity against all four cancer cell lines and the highest selectivity against K562 and MDA-MB-453 cancer cell lines. The compounds inhibited tumor cell proliferation by arresting the cell cycle progression at the S phase. (C) 2010 Elsevier Inc. All rights reserved.en
heal.journalNameJ Inorg Biochemen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
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