Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85 (Journal article)

Tselios, T./ Daliani, I./ Deraos, S./ Thymianou, S./ Matsoukas, E./ Troganis, A./ Gerothanassis, I./ Mouzaki, A./ Mavromoustakos, T./ Probert, L./ Matsoukas, J.

In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP72-85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Alas(81)MBP(72-85). The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP72-85 and cyclo(2-9)MBP72-85. (C) 2000 Elsevier Science Ltd. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: peptide analogs,angiotensin-ii,lymphocyte-t,conformation,backbone,ligands,clones,domain,rat
ISSN: 0960-894X
Link: <Go to ISI>://000165849700006
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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