Treatment of experimental allergic encephalomyelitis (EAE) by a rationally designed cyclic analogue of myelin basic protein (MBP) epitope 72-85 (Journal article)

Tselios, T./ Daliani, I./ Deraos, S./ Thymianou, S./ Matsoukas, E./ Troganis, A./ Gerothanassis, I./ Mouzaki, A./ Mavromoustakos, T./ Probert, L./ Matsoukas, J.


In this report the rational design, synthesis and pharmacological properties of an amide-linked cyclic antagonist analogue of the guinea pig myelin basic protein epitope MBP72-85 are described. Design of the potent cyclic analogue was based on 2D NOESY nuclear magnetic resonance and molecular dynamics studies carried out in the linear antagonist Alas(81)MBP(72-85). The cyclic antagonist completely prevented the induction of experimental allergic/autoimmune encephalomyelitis when coinjected with linear and cyclic agonist analogues MBP72-85 and cyclo(2-9)MBP72-85. (C) 2000 Elsevier Science Ltd. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: peptide analogs,angiotensin-ii,lymphocyte-t,conformation,backbone,ligands,clones,domain,rat
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/9783
ISSN: 0960-894X
Link: <Go to ISI>://000165849700006
http://ac.els-cdn.com/S0960894X00005564/1-s2.0-S0960894X00005564-main.pdf?_tid=a0e8d7eb08709cf1e847f2a848c7e6ad&acdnat=1333029910_2cffba4bb40d634dd8e10faab867f92f
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Tselios-2000-Treatment of experim.pdf469.84 kBAdobe PDFView/Open    Request a copy



 Please use this identifier to cite or link to this item:
http://olympias.lib.uoi.gr/jspui/handle/123456789/9783
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.