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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Tsimogiannis, K. E. | en |
| dc.contributor.author | Tellis, C. C. | en |
| dc.contributor.author | Tselepis, A. D. | en |
| dc.contributor.author | Pappas-Gogos, G. K. | en |
| dc.contributor.author | Tsimoyiannis, E. C. | en |
| dc.contributor.author | Basdanis, G. | en |
| dc.date.accessioned | 2015-11-24T16:51:39Z | - |
| dc.date.available | 2015-11-24T16:51:39Z | - |
| dc.identifier.issn | 0930-2794 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9765 | - |
| dc.rights | Default Licence | - |
| dc.subject | crp | en |
| dc.subject | il-6 | en |
| dc.subject | innate immunity | en |
| dc.subject | tnf alpha | en |
| dc.subject | tlrs | en |
| dc.subject | surgical stress | en |
| dc.subject | innate immunity | en |
| dc.subject | assisted colectomy | en |
| dc.subject | randomized-trial | en |
| dc.subject | colon-cancer | en |
| dc.subject | surgery | en |
| dc.subject | expression | en |
| dc.subject | recognition | en |
| dc.subject | activation | en |
| dc.subject | resections | en |
| dc.title | Toll-like receptors in the inflammatory response during open and laparoscopic colectomy for colorectal cancer | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1007/s00464-011-1871-2 | - |
| heal.identifier.secondary | <Go to ISI>://000299293500005 | - |
| heal.identifier.secondary | http://www.springerlink.com/content/m12l11540jw6r545/fulltext.pdf | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2012 | - |
| heal.abstract | Surgical interventions activate a cascade of reactions that result in an aseptic inflammatory reaction. This inflammatory response initiates the organism's innate immunity. Laparoscopic surgery reduces the trauma, and patients benefit from diminished surgical trauma and maintained immune function. Cytokine levels and C-reactive protein (CRP) are related to the magnitude of surgical trauma and surgical stress. Toll-like receptors (TLRs) 2 and 4 are the first sensor-recognition receptors of the invading pathogens for the innate immune response. This study aimed to compare the inflammatory response and then the stress response during laparoscopic and open colectomy for cancer by calculating TLR-2 and TLR-4 as the first sensor-recognition receptors together with interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and high-sensitivity CRP (hsCRP). A total 40 patients with colorectal cancer were randomized in two groups: group A (open colectomy, n = 20) and group B (laparoscopic colectomy, n = 20). An epidural catheter was placed in all patients 1 h preoperatively. Rupivocaine was administered perioperatively and 48 h postoperatively. Blood samples were taken for calculation of IL-6, TNF-alpha, hsCRP, TLR-2, and TLR-4 preoperatively and 5 min after deflation of pneumoperitoneum (group B) or 5 min after division of the colon (group A), then 6 and 24 h postoperatively. The mean operative time was 115 for group A and 142 min for group B. The mean blood loss was respectively 240 and 105 ml (P < 0.001), and the mean hospital stay was respectively 8 and 5 days (P < 0.05). The IL-6 level was significant higher in group A than in group B at 6 and 24 h postoperatively (P < 0.0001), and the hsCRP level was significant higher in group A than in group B at 24 h postoperatively (P < 0.001). The TNF-alpha values did not differ between the two groups. The TLR-2 level was significantly higher in group A than in group B at 5 min (P = 0.013) and 24 h (P = 0.007) postoperatively. The TLR-4 level was significant higher in group A than in group B at 5 min postoperatively (P = 0.03). The inflammatory response and the resultant stress response are significantly less during laparoscopic colectomy than during open colectomy for colorectal cancer. This is an obvious short-term clinical benefit for the patient, providing tinder for further study to investigate the long-term results of laparoscopic colectomy versus open colectomy for colorectal cancer (Registered clinical trial no. NCT00942461; http://www.clinicaltrials.gov). | en |
| heal.publisher | Springer | en |
| heal.journalName | Surgical Endoscopy and Other Interventional Techniques | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Tsimogiannis-2012-Toll-like receptors.pdf | 319.81 kB | Adobe PDF | View/Open Request a copy |
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