Η επίδραση της χρόνιας ισχαιμίας οπισθίου άκρου στην έκταση του εμφράγματος του μυοκαρδίου, στην αγγειογένεση και στην παράπλευρη στεφανιαία ροή (Bachelor thesis)

Βαρνάβας, Βαρνάβας


Aim: We examined the effects of chronic ischemia of peripheral skeletal muscles on infarct size and neovascularization of myocardium. Methods: Hind-limb ischemia was induced in Wistar rats and New Zealand rabbits by excision of the left femoral artery. Four weeks thereafter, in the rat series, infarct size without reperfusion, left ventricular function after ischemia/reperfusion, neovascularization and coronary flow were determined, whereas in the rabbit series, infarct area/area at risk ratio (I/R ratio) after ischemia/reperfusion combined with conditioning protocol and neovascularization were assessed. Results: Chronic limb ischemia rats demonstrated smaller infarct size (p<0.0001), improved left ventricular function at the end of reperfusion (developed pressure: p=0.008; max+dp/dt: p=0.004; max-dp/dt: p=0.041), whereas coronary flow remained unchanged during ischemia (F=1.36, p=0.28) compared to the controls (F=5.65, p=0.00182). Chronic limb ischemia rabbits exhibited a smaller I/R ratio after ischemia/reperfusion and application of conditioning (p=0.003, p=0.0015, p=0.00014), while coronary vessel density was higher in both rat (0.00021) and rabbit series (p=0.008). Conclusion: Chronic ischemia of peripheral skeletal muscles confers cardioprotection, augmenting coronary collateral flow.
Alternative title / Subtitle: Πειραματική μελέτη
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής Τομέας Παθολογικός Κλινική Καρδιολογική Πανεπιστημιακού Γενικού Νοσοκομείου Ιωαννίνων
Subject classification: Μυοκάρδιο
Ασθένειες
NLG
Keywords: Χρόνια ισχαιμία περιφερικών σκελετικών μυών,Έμφραγμα μυοκαρδίου,Μέγεθος εμφράγματος μυοκαρδίου,Στεφανιαία ροή,Παράπλευρη στεφανιαία ροή,Αγγειογένεση,Ισχαιμική προετοιμασία,Μετα-ισχαιμική προετοιμασία
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/972
Link: http://thesis.ekt.gr/thesisBookReader/id/26034#page/1/mode/2up
Appears in Collections:Διδακτορικές Διατριβές

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