Antigen-Antibody Interactions Study by 2d-H-1 Nmr - Molecular Recognition between Decapeptide Analogs of the Acetylcholine-Receptor Alpha-67-76 Fragment and the Anti-Achr Antibodies (Journal article)

Cung, M. T./ Marraud, M./ Tsikaris, V./ Sakarellos, C./ Papadouli, I./ Tzartos, S. J.


To investigate the conformational role of the alpha-67-76 decapeptide fragment of the Torpedo acetylcholine receptor (AChR), each residue of the WNPADYGGIK sequence was substituted step by step by alanine. The 2D-NMR conformational study of the peptide analogues in the free state was carried out in DMSO. The COSY and transferred NOESY were applied to study the interactions of a monoclonal antibody (mAb6) directed against the main immunogenic region (MIR) of the AChR and five decapeptide analogues from the MIR.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: main immunogenic region,two-dimensional h-1-nmr,monoclonal-antibodies,localization,residues
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/9677
ISSN: 0021-7689
Link: <Go to ISI>://A1992HJ07500005
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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