The Metabolic Role of Retinol Binding Protein 4: An Update (Journal article)

Christou, G. A./ Tselepis, A. D./ Kiortsis, D. N.

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dc.contributor.authorChristou, G. A.en
dc.contributor.authorTselepis, A. D.en
dc.contributor.authorKiortsis, D. N.en
dc.rightsDefault Licence-
dc.subjectinsulin resistanceen
dc.subjectlipid metabolismen
dc.subjectadipose tissueen
dc.subjectmetabolic syndromeen
dc.subjectdensity-lipoprotein cholesterolen
dc.subjecttype-2 diabetes-mellitusen
dc.subjectfatty liver-diseaseen
dc.subjectserum retinol-binding-protein-4 levelsen
dc.subjectprimary human adipocytesen
dc.subjectmorbidly obese subjectsen
dc.titleThe Metabolic Role of Retinol Binding Protein 4: An Updateen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.primaryDOI 10.1055/s-0031-1295491-
heal.identifier.secondary<Go to ISI>://000298698600002-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείαςel
heal.abstractRetinol binding protein 4 (RBP(4)) is regarded as a novel cardiometabolic risk factor, which is secreted mainly by the hepatocytes and also by the adipose tissue. RBP(4) has been shown to induce insulin resistance, and plasma RBP(4) values are increased in type 2 diabetes mellitus, obesity, metabolic syndrome, and cardiovascular disease. Moreover, it has been found that circulating RBP(4) decreases during medical interventions that result in amelioration of the metabolic profile, such as diet, exercise, oral antidiabetic drugs, and hypolipidemic agents. However, only few of the RBP(4)-related studies have investigated whether RBP(4) constitutes a causal factor of the above-mentioned metabolic conditions. Importantly, circulating RBP(4) is influenced by some nonmetabolic conditions, such as renal failure, acute illness, injury, and liver failure. Thus, further studies investigating the metabolic roles of RBP(4) should be carefully planned, taking into account the effects of nonmetabolic conditions on circulating RBP(4).en
heal.journalNameHormone and Metabolic Researchen
heal.journalTypepeer reviewed-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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