Synthesis of Thieno[2,3-D]Pyrimidines from 4,6-Dichloropyrimidine-5-Carbaldehydes (Journal article)

Clark, J./ Shahhet, M. S./ Korakas, D./ Varvounis, G.

Several thieno[2,3-d]pyrimidines have been prepared by intramolecular cyclisation of 6-(substituted methylthio)-5-pyrimidinecarbaldehyde and carbonitrile intermediates derived from 6-chloropyrimidine-5-carbaldehydes and 5-carbonitriles and methyl thioglycolate or 5-formylpyrimidine-4-(3H)-thiones and appropriate alpha-halogeno compounds. Thienopyrimidines 18 and 5c were nitrated to the corresponding nitro compounds 23 and 24. Hydrolysis at position 4 of compound 18 also occurred during nitration. The ester 5g was hydrolysed in base to the acid 25.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: pyrimidine-derivatives
ISSN: 0022-152X
Link: <Go to ISI>://A1993MD59700039
Publisher: Wiley-Blackwell
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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