Synthesis of a novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid with strong cytotoxicity in vitro (Journal article)

Xanthopoulou, M. N./ Hadjikakou, S. K./ Hadjiliadis, N./ SchΓΌrmann, M./ Jurkschat, K./ Binolis, J./ Karkabounas, S./ Charalabopoulos, K.

A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (Hzmna) of formula {[(C6Hs)3Sn]E(mna)"™[(CH3)2CO]} (1) has been synthesized and characterized by elemental analysis and 13C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2,mercaptonicotinic acid (HEmna). It is an example of a pentacoordinated Ph3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: triphenyltin(IV) compound, S ligands-heterocyclic thioamides, mercaptonicotinic acid, crystal structures
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/9451
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Hadjikakou-2003-Synthesis of a novel.pdf482.02 kBAdobe PDFView/Open


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/9451
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.