Structure and function of the myelin proteins: Current status and perspectives in relation to multiple sclerosis (Journal article)

Tzakos, A. G./ Kursula, P./ Troganis, A./ Theodorou, V./ Tselios, T./ Svarnas, C./ Matsoukas, J./ Apostolopoulos, V./ Gerothanassis, I. P.

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by demyelination and loss of neurological function, local macrophage infiltrate and neuroantigen-specific CD4(+)T cells. MS arises from complex interactions between genetic, immunological, infective and biochemical mechanisms. Although the circumstances of MS etiology remain hypothetical, one persistent theme involves immune system recognition of myelin-specific antigens derived from myelin basic protein, the most abundant extrinsic myelin membrane protein, and/or another equally suitable myelin protein or lipid. Knowledge of the biochemical and physico-chemical properties of myelin proteins and lipids, particularly their composition, organization, structure and accessibility with respect to the compacted myelin multilayers, becomes central to understanding how and why myelin-specific antigens become selected during the development of MS. This review focuses on the current understanding of the molecular basis of MS with emphasis: (i) on the physical-chemical properties, organization, morphology, and accessibility of the proteins and lipids within the myelin multilayers; (ii) on the structure-function relationships and characterization of the myelin proteins relevant to the manifestation and evolution of MS; (iii) on conformational relationships between myelin epitopes which might become selected during the development of MS; (iv) on the structure of MHC/HLA in complex with MBP peptides as well as with TCR, which is crucial to the understanding of the pathogenesis of MS with the ultimate goal of designed antigen-specific treatments.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: multiple sclerosis,proteins of the myelin sheath,mbp,mhc,tcr,docking,epitopes,structure,marie-tooth disease,central-nervous-system,experimental allergic encephalomyelitis,2',3'-cyclic nucleotide 3'-phosphodiesterase,major histocompatibility complex,oligodendrocytic basic-protein,class-ii molecule,calcium-binding proteins,amino-acid-sequences,peripheral myelin
ISSN: 0929-8673
Link: <Go to ISI>://000229295700010
Publisher: Bentham Science Publishers
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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