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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Lazarou, K. | en |
| dc.contributor.author | Bednarz, B. | en |
| dc.contributor.author | Kubicki, M. | en |
| dc.contributor.author | Verginadis, I. I. | en |
| dc.contributor.author | Charalabopoulos, K. | en |
| dc.contributor.author | Kourkoumelis, N. | en |
| dc.contributor.author | Hadjikakou, S. K. | en |
| dc.date.accessioned | 2015-11-24T16:48:10Z | - |
| dc.date.available | 2015-11-24T16:48:10Z | - |
| dc.identifier.issn | 0020-1693 | - |
| dc.identifier.uri | https://olympias.lib.uoi.gr/jspui/handle/123456789/9291 | - |
| dc.rights | Default Licence | - |
| dc.subject | bioinorganic chemistry | en |
| dc.subject | copper(i) complexes | en |
| dc.subject | triphenylphosphine | en |
| dc.subject | crystal structures | en |
| dc.subject | photolysis | en |
| dc.subject | biological studies | en |
| dc.subject | cytotoxic activity | en |
| dc.subject | coinage metal-clusters | en |
| dc.subject | d-orbital aromaticity | en |
| dc.subject | crystal-structure | en |
| dc.subject | heterocyclic thiones | en |
| dc.subject | molecular structure | en |
| dc.subject | ligand | en |
| dc.subject | triphenylphosphine | en |
| dc.subject | hydrocarbons | en |
| dc.subject | mononuclear | en |
| dc.subject | phosphine | en |
| dc.title | Structural, photolysis and biological studies of the bis(mu(2)-chloro)-tris(triphenylphosphine)-di-copper(I) and chloro-tris(triphenylphosphine)- copper(I) complexes. Study of copper(I)-copper(I) interactions | en |
| heal.type | journalArticle | - |
| heal.type.en | Journal article | en |
| heal.type.el | Άρθρο Περιοδικού | el |
| heal.identifier.primary | DOI 10.1016/j.ica.2009.11.037 | - |
| heal.identifier.secondary | <Go to ISI>://000274414700018 | - |
| heal.identifier.secondary | http://ac.els-cdn.com/S0020169309006859/1-s2.0-S0020169309006859-main.pdf?_tid=85e2309d8acd95b105acc47dd78d87c3&acdnat=1333030236_d690a9ffb4ec6bc848cd6be8f7fcab5a | - |
| heal.language | en | - |
| heal.access | campus | - |
| heal.recordProvider | Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας | el |
| heal.publicationDate | 2010 | - |
| heal.abstract | Direct reaction of copper(I) chloride with triphenylphosphine (tpp) in molar ratio 2: 3 and 1: 3, results in the formation of the [(tpp)Cu(mu(2)-Cl)(2)Cu(tpp)(2)] (1) and {[CuCl(tpp)(3)]center dot(CH(3)CN)} (2) complexes. The complexes have been characterized by melting point, FT-IR, UV-Vis spectroscopic data and X-ray crystallography. Complex 1 is di-nuclear. Two mu(2)-Cl atoms bridge two copper(I) ions with tetrahedral and trigonal geometry respectively. The short copper-copper bond distance of 2.9039(6) angstrom in case of 1 indicates d(10)-d(10) interaction between metal centers. Thus, our studies were extended here in the determination of the quasi-aromaticity, which results in strong Cu-Cu interactions, using the computational method of nucleus-independent chemical shifts (NICS). The NICS calculated at the inner region of the Cu(2)Cl(2)P(3) core in complex 1 is shielded up to -6.05 ppm. Complex 2 is mono-nuclear where three phosphorus and one chloride atoms form a tetrahedron around the copper(I) ion. Photolysis of both complexes 1 and 2, results in the formation of triphenylphosphine oxide. The complexes 1 and 2, were tested for their in vitro cytotoxic activity against leiomyosarcoma cells (LMS) and human breast adenocarcinoma cells (MCF-7). The type of LMS cell death caused by the complexes was also evaluated by use of a flow cytometry assay. The results show that at concentration of 5 mu M of complexes 1 and 2, 34.1% (1) and 19.6 (2)% of LMS cells undergo programmed cell death (apoptosis), while at 10 mu M, 80.4% (1) and 65.2% (2) of LMS cells undergo apoptosis. The light sensitivity of the complex is discussed in relation with the biological activity. (C) 2009 Elsevier B. V. All rights reserved. | en |
| heal.publisher | Elsevier | en |
| heal.journalName | Inorganica Chimica Acta | en |
| heal.journalType | peer reviewed | - |
| heal.fullTextAvailability | TRUE | - |
| Appears in Collections: | Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά). ΧΗΜ | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Lazarou-2010-Structural, photolys.pdf | 1.98 MB | Adobe PDF | View/Open Request a copy |
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