Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole (Journal article)

Kyros, L./ Kourkoumelis, N./ Kubicki, M./ Male, L./ Hursthouse, M. B./ Verginadis, I. I./ Gouma, E./ Karkabounas, S./ Charalabopoulos, K./ Hadjikakou, S. K.

The synthesis and characterization of the silver(I) chloride complex of formula {[AgCI(CMBZT)(TPTP)(2)] center dot (MeOH)} (1) (CMBZT = 5-chloro-2-mercaptobenzothiazole, TPTP = tris(p-tolyl) phosphine) is described. Also the structure of the hydrate derivative {[AgCI(TPTP)(3)] center dot (0.5 center dot H(2)O)} (2) of the corresponding known anhydrous silver complex (Zartilas et al., 2009), and the polymorph 3 of the known [AgI(TPTP)(3)] complex (Zartilas et al., 2009) were determined and compared with the known ones. In addition, the structure of the known one silver(I) cluster {[AgI(TPTP)](4)} (4) (Meijboom et al., 2009) was re-determined at 120(2) K and possible Ag-Ag interactions were analyzed. The compounds 1-4 were characterized by X-ray crystallography at r.t (1) and 120 K (2-4). All these complexes and {[(Et(3)NH)(+)](2) center dot [Ag(6)(mu(3)-Hmna)(4)(mu(3)-mna)(2)](2-) center dot (DMSO)(2) center dot (H(2)O)} (5) (Hmna = 2-mercaptonicotinic acid) were evaluated for cytotoxic and anti-inflammatory activity. The in vitro testing of cytotoxic activity of 1-5 against leiomyosarcoma cancer cells (LMS), were evaluated with Trypan Blue and Thiazolyl Blue Tetrazolium Bromide or 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assays. The flow cytometry assay for complex 1 and showed that at 15 mu M of 1, 62.38% of LMS cells undergo apoptosis, while 7% of LMS cells undergo cell necrosis. The antitumor activity of 3 is comparable with that of its reported polymorph (Zartilas et al., 2009). The anti-inflammatory, activity of complexes 1-3 and 5 was also studied. The activity towards cell viability was 2 > 3 > 5 > 1 > 4, while the order of the inhibitory activity in cell growth proliferation follows the order, 2 > 3 > 1 > 4 > 5. The anti-inflammatory activity on the other hand is 1 > 2 > 5 > ... > 3. Copyright (C) 2010 L. Kyros et al.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: d-orbital aromaticity,coinage metal-clusters,antiviral activity,crystal-structure,chemical-shifts,in-vitro,organotin(iv),ligands,acid,hydrocarbons
ISSN: 1565-3633
Link: <Go to ISI>://000277685000001
Publisher: Hindawi Publishing Corporation
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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