Stray Cu(II) may cause oxidative damage when coordinated to the -TESHHK- sequence derived from the C-terminal tail of histone H2A (Journal article)

Mylonas, M./ Malandrinos, G./ Plakatouras, J./ Hadjiliadis, N./ Kasprzak, K. S./ Krezel, A./ Bal, W.

CH3CO-Thr-Glu-Ser-His-His-Lys-NH2, a hexapeptide representing the 120-125 sequence of histone H2A, coordinates Cu(II) ions efficiently. Monomeric complexes are formed. In the major complex at physiological pH, CuH-1L, Cu(II) is coordinated equatorially through the imidazole nitrogen of the His-4 residue and the amide nitrogens of the Ser-3 and His-4 residues, and axially through the imidazole nitrogen of the His-5 residue. This complex reacts with H2O2 and the resulting reactive oxygen intermediate efficiently oxidizes 2 ' -deoxyguanosine. The underlying mechanism involves the formation of Cu(III) and a metal-bound hydroxyl radical species.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: copper(ii) complexes,reduction potentials,oxygen activation,pulse-radiolysis,3rd residue,nickel(ii),binding,stability,DNA,peptides
ISSN: 0893-228X
Link: <Go to ISI>://000171153800004
Publisher: American Chemical Society
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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