Alterations in the High Density Lipoprotein Phenotype and HDL-Associated Enzymes in Subjects with Metabolic Syndrome (Journal article)

Lagos, K. G./ Filippatos, T. D./ Tsimihodimos, V./ Gazi, I. F./ Rizos, C./ Tselepis, A. D./ Mikhailidis, D. P./ Elisaf, M. S.

Patients with metabolic syndrome (MetS) usually have low high density lipoprotein cholesterol (HDL-C) levels. We determined the HDL distribution profile as well as the HDL-related lipoprotein associated phospholipase A(2) (HDL-LpPLA(2)) and paraoxonase-1 (PON1) activities in subjects with MetS (n = 189) but otherwise healthy. Age and sex-matched individuals (n = 166) without MetS served as controls. The lower HDL-C concentration in MetS patients was due to a reduction in both large and small HDL subclasses (P < 0.001 and P < 0.05, respectively). As the number of MetS components increased, the HDL phenotype comprised of a greater percentage of small HDL-3 and less large HDL-2 subclasses, resulting in a decreased HDL-2/HDL-3 ratio (P < 0.001 for all trends). Multivariate analysis revealed that HDL-2 levels and the HDL-2/HDL-3 ratio significantly and independently correlated with HDL-C (positively) and TG (negatively) levels. HDL-3 concentration significantly and independently positively correlated with HDL-C and TG levels. HDL-LpPLA(2) activity was decreased in MetS patients (P < 0.01), a phenomenon that may contribute to the defective antiatherogenic activity of HDL in MetS. PON1 activity did not differ between groups. We conclude that MetS, in addition to the decrease in HDL-C concentration, is associated with alterations in the HDL phenotype, which is comprised of a greater percentage of small HDL subclasses. Furthermore, HDL-LpPLA(2) activity is decreased in MetS patients.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: metabolic syndrome,high density lipoprotein,subclasses,lipoprotein associated phospholipase a(2),paraoxonase 1,high sensitivity c-reactive protein,small dense low density lipoprotein cholesterol,triglycerides,activating-factor-acetylhydrolase,elevated oxidative stress,coronary-heart-disease,phospholipase a(2),diabetes-mellitus,antioxidative activity,cardiovascular events,paraoxonase activity,clinical importance,intervention trial
ISSN: 0024-4201
Link: <Go to ISI>://000261790800002
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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