Phospholipase A(2) subclasses in acute respiratory distress syndrome (Journal article)

Kitsiouli, E./ Nakos, G./ Lekka, M. E.


phospholipases A(2), (PLA(2)) catalyse the cleavage of fatty acids esterified at the sn-2 position of glycerophospholipids. In acute lung injury-acute respiratory distress syndrome (ALI-ARDS) several distinct isoenzymes appear in lung cells and fluid Some are capable to trigger molecular events leading to enhanced inflammation and lung damage and others have a role in lung surfactant recycling preserving lung function Secreted forms (groups sPLA(2)-IIA, -V, -X) can directly hydrolyze surfactant phospholipids Cytosolic PLA(2) (cPLA(2)-IVA) requiring Ca(2+) has a preference for arachidonate, the precursor of etcosanoids which participate in the inflammatory response in the lung. Ca(2+) independent intracellular PLA(2)s (iPLA(2)) take part in surfactant phospholipids turnover within alveolar cells Acidic Ca(2+) -independent PLA(2) (aiPLA(2)). of lysosomal origin. has additionally antioxidant properties, (peroxiredoxin VI activity). and participates in the formation of dipalmitoyl-phosphatidylcholine in lung surfactant. PAF-AH degrades PAF. a potent mediator of inflammation, and oxidatively fragmented phospholipids but also leads to toxic metabolites. Therefore, the regulation of PLA(2) isoforms could be a valuable approach for ARDS treatment. (C) 2009 Elsevier B.V All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: ali,ards,phospholipase a(2),pla(2),paf-ah,lung surfactant,inhibitors of pla(2),acute lung injury,platelet-activating-factor,arachidonic-acid release,surfactant protein-a,bronchoalveolar lavage fluid,airway epithelial-cells,intestinal ischemia-reperfusion,x secreted phospholipase-a(2),smooth-muscle-cells,m-type receptor
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/8807
ISSN: 0925-4439
Link: <Go to ISI>://000271071600002
http://ac.els-cdn.com/S0925443909001380/1-s2.0-S0925443909001380-main.pdf?_tid=25588c005c8a30f4395b2acd39f5691a&acdnat=1333033686_41946e413ba999479a179718bb8def8c
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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