Palladium(II) complexes of 2-acetylpyridine N(4)-propyl, N(4)-dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity. Synthesis, spectral properties, antifungal and in vitro antitumor activity (Journal article)

KovalaDemertzi, D./ Domopoulou, A./ Demertzis, M. A./ Papageorgiou, A./ West, D. X.

Some new palladium(II) complexes of 2-acetylpyridine N(4)-propyl-and N(4)dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity were described. The thiosemicarbazones and their palladium(II) complexes have been characterized by spectroscopic, and electrochemical techniques. The protonation constants of HAc4P K-a1 and K-a2, were determined by spectrophotometry and the pK(1a) and pK(a2) values are equal to 12.23 +/- 0.02 and 4.11 +/- 0.02. The antifungal properties and the effect selected compounds on DNA synthesis of P388 and L1210 cell cultures is reported. (C) 1997 Elsevier Science Ltd.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: new palladium complexes,2-acetylpyridine thiosemicarbazones,antitumor activity,metal ion complexes,copper(ii) complexes,redox behavior,thiosemicarbazones,n-4-dipropylthiosemicarbazones,n-4-diethylthiosemicarbazones,electrochemistry
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/8756
ISSN: 0277-5387
Link: <Go to ISI>://A1997XQ92400022
http://ac.els-cdn.com/S0277538797001071/1-s2.0-S0277538797001071-main.pdf?_tid=6a0549a33fd66837f4813a618bc57f30&acdnat=1333028721_c25fac89265570f2afe50784f3f8401f
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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