Palladium(II) and platinum(II) complexes of pyridine-2-carbaldehyde thiosemicarbazone with potential biological activity. Synthesis, structure and spectral properties. Extended network via hydrogen bond linkages of [Pd(PyTsc)Cl] (Journal article)

Kovala-Demertzi, D./ Miller, J. R./ Kourkoumelis, N./ Hadjikakou, S. K./ Demertzis, M. A.

The reactions of Li2PdCl4 and Na2PtCl4 with pyridine-2-carbaldehyde thiosemicarbazone, HPyTsc, afforded the complexes [Pd(PyTsc)Cl], [Pd(PyTsc)(2)] and [Pt(PyTsc)Cl], [Pt(PyTsc)(2)]. The new complexes have been characterized by elemental analyses and spectroscopic studies. A crystal structure of [Pd(PyTsc)Cl] shows that the anion of PyTsc coordinates in a planar conformation to the central palladium(II) through the pyridyl N, azomethine N and thiolato S atoms. The planar molecules are linked into polymeric chains by N-(HN)-N-.. and N-(HS)-S-.. hydrogen bonding. The protonation constants of the ligand. K-a1 and K-a2, were determined by spectrophotometry and the logarithms of their values were found to be equal to 11.58+/-0.05 and 3.94+/-0.02 respectively. Correlation of the antitumor activity of these complexes to the structure and to reduction potential is reported. The compounds [Pt(PyTsc)(2)] and [Pd(PyTsc)(2)] were found to exhibit the higher in vivo antitumor activity and the lower cytotoxicity. (C) 1999 Elsevier Science Ltd. All rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: palladium(ii) and platinum(ii) complexes,thiosemicarbazonato complexes,crystal study,spectroscopic and electrochemical studies,antitumor-activity,metal-complexes,in-vitro,2-acetylpyridine,electrochemistry,derivatives,antifungal,copper,pd(ii)
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/8751
ISSN: 0277-5387
Link: <Go to ISI>://000080231900011
http://ac.els-cdn.com/S0277538798003866/1-s2.0-S0277538798003866-main.pdf?_tid=44012329e8ab38d5568d70362e344b71&acdnat=1333028795_89548d7336bdc126ac0fb55386587230
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
Kovala-Demertzi-1999-Palladium(II) and pl.pdf279.83 kBAdobe PDFView/Open    Request a copy


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/8751
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.