O-17 Nmr and Ft-Ir Study of the Ionization State of Peptides in Aprotic-Solvents - Application to Leu-Enkephalin (Journal article)

Gerothanassis, I. P./ Birlirakis, N./ Karayannis, T./ Tsikaris, V./ Sakarellos-Daitsiotis, M./ Sakarellos, C./ Vitoux, B./ Marraud, M.

The ionization state of Leu-enkephalin in DMSO and MeCN/DMSO (4/1) solution was studied by the combined use of O-17 NMR and FT-IR spectroscopy. After lyophilization of an aqueous solution at nearly neutral pH. Leu-enkephalin essentially exists in the uncharged state in MeCN/DMSO (4/1) solution. In pure DMSO, only 40% of the Leu-enkephalin molecules are in the zwitterionic state under the same conditions.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: ft-ir,ionization state of peptide,leu-enkephalin,o-17 nmr,nuclear magnetic-resonance,<leu5>-enkephalin
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/8634
ISSN: 0014-5793
Link: <Go to ISI>://A1992HG04500022
http://ac.els-cdn.com/001457939280053J/1-s2.0-001457939280053J-main.pdf?_tid=105f439712c6d23337dba55be9eb78c3&acdnat=1333038451_1f8fd844ab213123e39bbf9c44c9f84c
Publisher: Elsevier
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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