Leptin and adiponectin levels in patients with ankylosing spondylitis. The effect of infliximab treatment (Journal article)

Derdemezis, C. S./ Filippatos, T. D./ Voulgari, P. V./ Tselepis, A. D./ Drosos, A. A./ Kiortsis, D. N.

Background. Adipose tissue-derived leptin and adiponectin control hunger, energy expenditure, insulin sensitivity, endothelial function, reproduction and immunity and are thought to play a role in autoimmune diseases. However, their role in ankylosing spondylitis (AS) is not clearly defined. Tumour necrosis factor TNF-alpha is a potential modulator of adipocytokines. The effect of long-term anti-TNF-alpha treatment on plasma levels of leptin and adiponectin has not been assessed so far. Objectives. To assess the effect of a 6-month anti-TNF-alpha treatment on serum leptin and adiponectin levels in AS patients. Methods. Thirty men with AS were included in the study. Thirty age- and weight-matched men served as controls. Clinical and biochemical parameters were assessed and serum levels of leptin and adiponectin were measured with enzyme immunoassay methods prior to and after the 6-month treatment with infliximab. Results. Mean age and disease duration of AS patients were 40.6+/-13.7 and 13.4+/-8.4 years, respectively. At baseline, AS patients exhibited significantly higher adiponectin (15.4+/-8.3 vs. 8.6+/-4.2 p<0.05), but no difference in leptin levels (7.2+/-2.9 vs. 8.9+/-6.4 ng/ml, p=NS). Adipocytokines did not correlate with any disease parameter. Body weight of the patients did not change significantly over the 6-month period. Serum levels of leptin and adiponectin did not change significantly otter the 6-month treatment. Conclusion. Adiponectin levels were significantly higher in AS patients compared with controls. Infliximab treatment did not change serum levels of leptin and adiponectin suggesting that the anti-TNF-alpha treatment may not modulate significantly their levels.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: ankylosing spondylitis,infliximab,tnf,leptin,adiponectin,rheumatoid-arthritis,adipose-tissue,disease-activity,plasma-levels,inflammation,adipokines,therapy,index,mediators,insulin
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/8347
ISSN: 0392-856X
Link: <Go to ISI>://000286918800012
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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