Inhibition of lipoxygenase (LOX) and anticancer activity caused by gold(I) mixed ligands complexes of triphenylphosphine and thioamides (Journal article)

Georgiou, E./ Metsios, A./ Kourkoumelis, N./ Karkabounas, S./ Charalabopoulos, K./ Badeka, A./ Hadjikakou, S. K.

Four mixed ligand gold(I) complexes with the thioamides 2-mercapto-thiazolidine (mtzdH), 2-mercapto-benzothiazole (mbztH) and 5-chloro-2-mercapto-benzothiazole (ClmbztH) and triphenylphosphine (tpp) of formulae [Au(tpp) Cl] (1) [Au(tpp)(mtzd)] (2), [Au(tpp)(mbzt)] (3) and [Au(tpp)(Clmbzt)] (4), already known, were used to study their mechanism of inhibition activity towards the catalytic oxidation of linoleic acid to hydroperoxylinoleic acid by the enzyme lipoxygenase (LOX), kinetically and theoretically. The results are compared to those of cisplatin. In addition, the anticancer cell screening results against leimyosarcoma (LMS) cells have shown that 2-4 complexes were more active than cisplatin. The uptake of complexes in LMS cells were also studied with electrospray ionisation mass spectrometry spectroscopy.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: bioinorganic chemistry,gold(i) complexes,thioamides,biological studies,lipoxygenase inhibition,linoleic-acid,organotin(iv),derivatives,silver(i)
ISSN: 1475-6366
Link: <Go to ISI>://000292266000018
Publisher: Informa Healthcare
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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