Gravimetric and Spectrophotometric Methods for the Determination of Piperazine - Picrolonic Vs Picric Acid (Journal article)
Prodromidis, M. I./ Veltsistas, P. G./ Karayannis, M. I.
In the present work two new analytical methods, a gravimetric and a spectrophotometric, for the assay of piperazine free base and its soluble salts in the anthelmitic preparation ''Oxyuran'', are described. Both approaches are based on the quantitative reaction between the diprotonated cationic form of piperazine and the 3-methyl-4-nitro-1-p-nitrophenyl-5-pyrazolone (picrolonic acid), in sulfuric acid medium, leading to its sparingly soluble canary yellow salt. Both methods exhibit satisfactory levels of mean errors 1.2% and 1.7% respectively. The proposed picrolonate gravimetric method constitutes an improvement of the classical picric acid method regarding the accuracy, sensitivity and selectivity. The two gravimetric methods were compared. Good correlation was achieved, r=0.998. The improvement in sensitivity of the new spectrophotometric method is attributed to the high molar extinction coefficient epsilon(max)=18.770 mol(-1)l cm(-1) of the picrolonates at the measuring wavelength range lambda(max)=342-345 nm. Triethanolammonium-picrolonate and piperazine-diacetate were synthetized and standardized during this work.
|Institution and School/Department of submitter:||Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας|
|Link:||<Go to ISI>://A1994QE25700007|
|Appears in Collections:||Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)|
Files in This Item:
There are no files associated with this item.
Please use this identifier to cite or link to this item:This item is a favorite for 0 people.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.