Gene polymorphisms affecting HDL-cholesterol levels in the normolipidemic population (Journal article)

Miltiadous, G./ Hatzivassiliou, M./ Liberopoulos, E./ Bairaktari, E./ Tselepis, A./ Cariolou, M./ Elisaf, M.

Background and Aim: HDL-cholesterot (HDL-C) is inversely related to the risk of ischemic heart disease. Many genes are reported to affect HDL-C serum levels in both hyperlipidemic and normolipidemic populations, though the data are controversial. We examined the effect of common gene polymorphisms known to interfere with HDL-C metabolism (apolipoprotein E, cholesterol ester transfer protein and apolipoprotein A-IV gene polymorphisms) on HDL-C plasma levels in normolipidemic subjects. Methods and results: The study population consisted of 200 normolipidernic individuals visiting our clinic for a routine check-up. None of the above gene polymorphisms affected HDL-C levels in our population. However, participants carrying the atlete E4 of the apolipoprotein (apo) E gene, the allele B1 of the TaqIB polymorphisms in the cholesterol ester transfer protein (CETP) gene and the allele T of the apoA-IV gene (A to T polymorphism at site 347) (n=28) had statistically significantly tower HDL-C levels compared to those not carrying the above allele combination (0.99+0.33 vs 1.28 0.35 mmol/L, p=0.04). Conclusion: In this study, we describe a subgroup of normolipidemic individuals with low HDL-C levels due to genetic variability, and we discuss the underlying possible mechanisms involved. (c) 2005 Elsevier Ltd. All. rights reserved.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Keywords: hdl-cholesterol,genes,apolipoprotein e,apolipoprotein a iv,cholesterol ester transfer protein,apolipoprotein-a-iv,high-density-lipoproteins,transfer protein-activity,frequency,heterogeneity,sites,locus,cetp
ISSN: 0939-4753
Link: <Go to ISI>://000230318700010
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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