Μελέτη της αγγειίτιδας στα κακοήθη λεμφώματα και την χρόνια λεμφογενή λευχαιμία (Doctoral thesis)

Κλούβας, Γεώργιος Δ.

DURING THE LAST SEVEN YEARS (1986-1992) AT THE ONCOLOGY DEPARTMENT OF THE IOANNINA UNIVERSITY WE HAD THE OPPORTUNITY TO FOLLOW UP 100 CASES OF NON-HODGKIN LYMPHOMA (NHL) AND 25 CASES OF CHRONIC LYMPHOCYTIC LEUKEMIA (CLL). FOURTEEN PATIENTS, 7 WITH NHL AND 7 WITH CLL, DEVELOPED HISTOLOGICALLY PROVEN CUTANEOUSVASCULITIS. ALL PATIENTS HAD LABORATORY WORK-UP CONSISTING OF FULL BLOOD COUNT, ERYTHROCYTE SEDIMENTATION RATE IMMUNOELECTROPHORESIS AND AUTOIMMUNE PROFILE (RHEUMATOID FACTOR, C3 AND C4 COMPONENTS, ANTINUCLEAR ANTIBODIES, ANTIBODIES AGAINST EXTRACTABLE NUCLEAR ANTIGENS, DOUBLE-STANDED DNA AND CARDIOLIPIN AS WELL AS CRYOGLOBULINS). MOST OF THE PATIENTS (13/14) HAD ADVANCED (STAGEIII OR IV) B-CELL MALIGNANCY OF LOW OR INTERMEDIATE GRADE. ALSO 13/14 DEVELOPED VASCULITIS IN A MEDIAN TIME OF 32 MONTHS (RANGE 2-122) FOLLOWING THE DIAGNOSIS OF THE NHL OR CLL. VASCULITIS INVOLVED MAINLY THE SKIN AND WAS CHARACTERIZED BY A PALPABLE MACULOPAPULAR OR PAPULAR RUSH USUALLY FOUND IN THE UPPER EXTREMITIES. SOME PATIENTS HAD OTHER AUTOIMMUNE SYMPTOMS OR FINDINGS SUCH AS PERIPHERAL NEUROPATHY, ARTHRITIS, HEMOLYTIC ANEMIA AND RAYNAUD PHENOMENON.MOST OF THE PATIENTS (10/14) HAD MULTIPLE RECURRENT EPISODES UNRELATED TO EITHER THE COURSE OF THE UNDERLYING DISEASE OR THE TREATMENT. THUS IT SEEMS THAT THE DEVELOPMENT OF SKIN VASCULITIS IS NOT RELATED TO DISEASE ACTIVITY AND HAS NOT ANY PROGNOSTIC ROLE ON THE LYMPHOMA OUTCOME. (ABSTRACT TRUNCATED)
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων Σχολή Ιατρικής Τμήμα Ιατρικής
Subject classification: Αγγειίτιδα
Λεμφογενής λευχαιμία
Keywords: Αγγειΐτιδα,Λεμφώματα,Λευχαιμία, χρόνια λεμφοκυτταρική
URI: https://olympias.lib.uoi.gr/jspui/handle/123456789/796
http://dx.doi.org/10.26268/heal.uoi.832
Link: http://thesis.ekt.gr/thesisBookReader/id/2930#page/1/mode/2up
Appears in Collections:Διδακτορικές Διατριβές

Files in This Item:
There are no files associated with this item.


 Please use this identifier to cite or link to this item:
https://olympias.lib.uoi.gr/jspui/handle/123456789/796
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.