1. Repository of OAI
  2. ΑΠΟΘΕΤΗΡΙΟ "ΟΛΥΜΠΙΑΣ"
  3. Σχολή Επιστημών Υγείας
  4. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
  5. Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)
Ελληνικά   English  
Please use this identifier to cite or link to this item: https://olympias.lib.uoi.gr/jspui/handle/123456789/7925
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDuez, C.en
dc.contributor.authorTsicopoulos, A.en
dc.contributor.authorJanin, A.en
dc.contributor.authorTillieLeblond, I.en
dc.contributor.authorThyphronitis, G.en
dc.contributor.authorMarquillies, P.en
dc.contributor.authorHamid, Q.en
dc.contributor.authorWallaert, B.en
dc.contributor.authorTonnel, A. B.en
dc.contributor.authorPestel, J.en
dc.date.accessioned2015-11-24T16:35:16Z-
dc.date.available2015-11-24T16:35:16Z-
dc.identifier.issn0014-2980-
dc.identifier.urihttps://olympias.lib.uoi.gr/jspui/handle/123456789/7925-
dc.rightsDefault Licence-
dc.subjectallergyen
dc.subjectinhalationen
dc.subjectscid mouseen
dc.subjectinflammationen
dc.subjectsevere combined immunodeficiencyen
dc.subjectblood mononuclear-cellsen
dc.subjecthuman peripheral-blooden
dc.subjectmessenger-rnaen
dc.subjectatopic subjectsen
dc.subjectimmune-systemen
dc.subjectmast-cellsen
dc.subjectt-cellsen
dc.subjectinductionen
dc.subjectasthmaen
dc.titleAn in vivo model of allergic inflammation: Pulmonary human cell infiltrate in allergen-challenged allergic Hu-SCID miceen
heal.typejournalArticle-
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.identifier.secondary<Go to ISI>://A1996UT53100019-
heal.languageen-
heal.accesscampus-
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.publicationDate1996-
heal.abstractCB.17 severe combined immunodeficient (SCID) mice were used to establish a model of allergic pulmonary inflammation. SCID mice were intraperitoneally reconstituted with 10(7) peripheral blood mononuclear cells (PBMC) from patients sensitive to Dermatophagoides pteronyssinus (Dpt) and 2 weeks later were exposed to Dpt aerosols. After Dpt nebulization, SCID mice engrafted with PBMC from Dpt-sensitive patients developed a specific human ISE response as well as an intense pulmonary infiltrate of human cells. In contrast, SCID mice reconstituted with PBMC from patients allergic to grass pollen or from non-allegic donors failed to produce IgE or to exhibit a similar inflammatory response. The level of the IgE production was dependent on the IgE level of the allergic donor In the lungs of the same allergic SCID mice, 2 months after Dpt inhalation, the cell infiltrate contained CD45(+), CD45RO(-), CD20(+) and HLA-DR(+) human cells. They were located in perivascular and peribronchial areas and disseminated in the mouse lung parenchyma. Moreover mRNA IL-5(+) cells and eosinophils were found in peribronchial infiltrates. The observations indicate that humanized allergic SCID mice may develop, after nebulization with the relevant allergen, immune reactions similar to those observed in man and suggest that SCID mice may represent a useful model to analyze the regulatory mechanisms of IgE-associated allergic diseases.en
heal.journalNameEur J Immunolen
heal.journalTypepeer reviewed-
heal.fullTextAvailabilityTRUE-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Show simple item record
Files in This Item:
There are no files associated with this item.
Show simple item record  


This item is licensed under a Creative Commons License Creative Commons