Poly(A)-polymerase activity in chronic lymphocytic leukemia of the B cell type (Journal article)

Pangalis, G. A./ Trangas, T./ Papanastasiou, C. J./ Roussou, P. A./ Tsiapalis, C. M.

Full metadata record
DC FieldValueLanguage
dc.contributor.authorPangalis, G. A.en
dc.contributor.authorTrangas, T.en
dc.contributor.authorPapanastasiou, C. J.en
dc.contributor.authorRoussou, P. A.en
dc.contributor.authorTsiapalis, C. M.en
dc.rightsDefault Licence-
dc.subjectBone Marrow/pathologyen
dc.subjectLeukemia, Lymphoid/classification/*enzymology/pathologyen
dc.subjectPolynucleotide Adenylyltransferase/*metabolismen
dc.subjectTissue Extractsen
dc.titlePoly(A)-polymerase activity in chronic lymphocytic leukemia of the B cell typeen
heal.type.enJournal articleen
heal.type.elΆρθρο Περιοδικούel
heal.recordProviderΠανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιώνel
heal.abstractPoly(A)-polymerase enzymic activity was biochemically determined in lymphocytic extracts from 40 patients with chronic lymphocytic leukemia of the B cell type. The enzymic activities of patients with stage A, B and C disease were (U/mg of protein): 4.9 +/- 5.5, 12.5 +/- 7.5 and 20.9 +/- 18.9, respectively. The difference in the enzyme level between stage A and C patients was statistically significant (p less than 0.05). Comparison of the enzyme activity level in relation to the pattern of bone marrow involvement revealed that patients with a diffuse pattern of infiltration had a significantly higher enzyme level (17.9 +/- 15.5 U/mg of protein) than patients with interstitial or mixed infiltration patterns (5.9 +/- 6.6 and 7.9 +/- 7.0 U/mg of protein; p less than 0.025). Finally, patients who required treatment for their disease also had a significantly higher poly(A)-polymerase activity level (14.5 +/- 13.9 U/mg of protein) than patients with stable disease (4.9 +/- 5.5 U/mg of protein; p less than 0.05). Our results indicate that the enzyme poly(A)-polymerase may be used as a biological marker in patients with chronic lymphocytic leukemia.en
heal.journalNameActa Haematolen
heal.journalTypepeer reviewed-
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

Files in This Item:
File Description SizeFormat 
tranga-1985-polya-polymerase activity in chronic lymphocytic.pdf6.76 MBAdobe PDFView/Open    Request a copy

 Please use this identifier to cite or link to this item:
  This item is a favorite for 0 people.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.