Adjuvant activity of type I interferons (Journal article)

Tovey, M. G./ Lallemand, C./ Thyphronitis, G.


Type I interferons (IFNs) produced primarily by plasmacytoid dendritic cells (pDCs) as part of the innate immune response to infectious agents induce the maturation of myeloid DCs and enhance antigen presentation. Type I IFNs also enhance apoptosis of virus-infected cells, stimulate cross priming and enhanced presentation of viral peptides. Type I IFNs are powerful polyclonal B-cell activators that induce a strong primary humoral immune response characterized by isotype switching and protection against virus challenge. Type I IFNs stimulate an IgG2a antibody response characteristic of Th1 immunity when ad-mixed with influenza virus vaccine and injected intramuscurarly (i.m.) or administered intranasally. The adjuvant activity of type I IFNs has been shown to involve direct effects of IFN on B-cells, effects on T-cells, as well as effects on antigen presentation. Oromucosal administration of type I IFNs concomitantly with i.m. injection of vaccine alone can also enhance the antibody response to influenza vaccination by enhancing trafficking of antigen-presenting cells towards the site of vaccination. Recombinant IFNs are potent adjuvants that may find application in both parenterally and mucosally administered vaccines.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Keywords: adjuvant,apoptosis,cytokines,interferons,toll-like receptor (tlr),vaccination,quality-of-life,t-cells,dendritic cells,signaling pathways,direct stimulation,adaptive immunity,influenza vaccine,viral-infection,ifn-alpha,phase-ii
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/7760
ISSN: 1431-6730
Link: <Go to ISI>://000255439000009
http://www.degruyter.com/dg/viewarticle.fullcontentlink:pdfeventlink/contentUri?t:ac=j$002fbchm.2008.389.issue-5$002fbc.2008.051$002fbc.2008.051.xml
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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