Wnt signaling and neural stem cells: caught in the Wnt web (Journal article)

Michaelidis, T. M./ Lie, D. C. C.


Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Keywords: signaling,wnt,stem cell,neurogenesis,development,terminal-binding-protein,central-nervous-system,nuclear beta-catenin,adult dentate gyrus,dorsal spinal-cord,notch target genes,wnt/beta-catenin,neuronal differentiation,progenitor cells,in-v
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/7753
ISSN: 0302-766X
Item type: journalArticle
Link: <Go to ISI>://000251618500017
http://www.springerlink.com/content/m061132831k114l2/fulltext.pdf
Item language: en
Item access scheme: campus
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Publication date: 2008
Abstract: Wnt proteins have now been identified as major physiological regulators of multiple aspects of stem cell biology, from self-renewal and pluripotency to precursor cell competence and terminal differentiation. Neural stem cells are the cellular building blocks of the developing nervous system and provide the basis for continued neurogenesis in the adult mammalian central nervous system. Here, we outline the most recent advances in the field about the critical factors and regulatory networks involved in Wnt signaling and discuss recent findings on how this increasingly intricate pathway contributes to the shaping of the developing and adult nervous system on the level of the neural stem cell.
Journal name: Cell Tissue Res
Journal type: peer reviewed
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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