Relation between the activity of poly(A)polymerase and the levels of protein synthesis in the lymphocytes of patients with chronic lymphocytic leukemia (Journal article)

Gounaris, A./ Courtis, N./ Pangalis, G. A./ Tsiapalis, C. M./ Trangas, T.


The activity levels of the enzyme poly(A)polymerase and the levels of protein synthesis primed by endogenous messenger RNA (mRNA) as well as polyuridylic acid, poly(U) directed polyphenylalanine synthesis, were determined in lymphocytic extracts from 17 patients with chronic lymphocytic leukemia of the B cell type. The enzyme activity values have not been found to correlate with the poly(U)-protein synthesis, whereas a positive linear correlation has been established between the activity levels of poly(A)polymerase and the endogenous mRNA-primed protein synthesis (r = 0.735, p less than 0.01). This difference between exogenously and endogenously primed protein synthesis in concern with poly(A)polymerase is discussed.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών και Τεχνολογιών. Τμήμα Βιολογικών Εφαρμογών και Τεχνολογιών
Keywords: Humans,Leukemia, Lymphocytic, Chronic, B-Cell/*enzymology,Lymphocytes/*enzymology,Neoplasm Proteins/biosynthesis/*blood,Nucleotidyltransferases/*blood,Poly U/genetics,Polynucleotide Adenylyltransferase/*blood,Prognosis,Protein Biosynthesis,RNA,
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/7539
ISSN: 0006-5242
Link: http://www.ncbi.nlm.nih.gov/pubmed/2848602
Appears in Collections:Άρθρα σε επιστημονικά περιοδικά ( Ανοικτά)

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