Numerical modelling of bone fracture healing under the ultrasound effect (Master thesis)

Συντυχάκη, Αικατερίνη


Bone healing is a complicated process during which plenty of cellular and molecular mechanisms occur. The main objective of this study was the presentation of a computational model that simulates these cellular mechanisms during fracture healing and the effects of Low Intensity Pulsed Ultrasound (LIPUS) on bone fracture healing, in order to examine the effect which causes the enhancement of bone healing. The hybrid biological mathematical model is based on that of Peiffer et al. (2011). The model consists of a system of partial differential equations (PDEs) which describes the spatiotemporal evolution of cell, growth factors, tissues, oxygen and nutrients and acoustic pressure. It was assumed that the ultrasound affects Vascular Endothelial Growth Factor (VEGF) transport, as several in vitro studies have reported. Using velocity equations, the growth of the blood vessel network was described. As a result, this model could be a step towards a better understanding of the influence of ultrasound on fracture healing. However, more experiments should be conducted along with the advancement of a more detailed theoretical background.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Πολυτεχνική Σχολή. Τμήμα Μηχανικών Επιστήμης Υλικών
Subject classification: Modeling
Keywords: Πώρωση κατάγματος,Μοντελοποίηση,Υπέρηχοι,Evacture healing,Modeling,Ultrasound,Bone,Οστό
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/29430
Appears in Collections:Διατριβές Μεταπτυχιακής Έρευνας (Masters)

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