Synthesis, characterization, biological activity of new fluorescent complexes of Cu(I/II) with ligands dipicolinic acid and/or triphenylphosphine (Master thesis)

Μοσχοβίτης, Κωνσταντίνος

Copper is a chemical element of great biological interest. It has been shown that complex compounds with metals such as Cu, Ag, Au, Zn, Sn with various ligands exhibit antimicrobial activity. This activity is related to the interaction of these complexes with the bacterial DNA. The use of antibiotic drugs to combat certain pathogenic microorganisms has led to the development of resistant strains of microbes. Therefore, it is imperative to produce chemotherapeutic compounds with antimicrobial activity that are not antibiotics. This work describes the synthesis, characterization and biological activity of complex copper compounds with substituents triphenylphosphine and dipicolinic acid. Dipicolinic acid is a natural product produced by certain types of bacteria in the formation of resistant structures, the endospores. In total 4 complex compounds, 2 new and 2 re-synthesized were characterized, characterized by melting point, IR, NMR and X-ray crystallography. The stability of the complexes in DMSO solvent was studied using UV and NMR spectroscopy. Their interaction with CT-DNA was studied. Their antimicrobial activity against Pseudomonas aeuroginosa was also studied via inhibition zone, and the minimum inhibition concentration MIC was determined. Fluorescence of these complexes was also measured for their use in a new fluorescence detection method for endospores. Finally, their biomimetic catalytic effect on the oxidation of 3,5-di-tert-butyl catechol to the corresponding o-quinone was studied.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Θετικών Επιστημών. Τμήμα Χημείας
Subject classification: Χημεία, Ανόργανη
Keywords: Βιολογική,Ανόργανη,Χημεία,Biological,Inorganic,Chemistry,Copper,Triphenylphosphine,Dipicolinic acid,DNA,Antimicrobial compounds,Superoxide dismutase,Χαλκός,Τριφαινυλοφωσφίνη,Διπικολινικό οξύ,Αντιμικροβιακές ενώσεις,Υπεροξειδική δισμουτάση
Appears in Collections:Διατριβές Μεταπτυχιακής Έρευνας (Masters)

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