The effect of peripheral nervous system in the growing bones of the upper limb (Doctoral thesis)

Γκιάτας, Ιωάννης Σ.

Purpose: The aim of the present experimental study is to determine the effect of the peripheral nervous system on the growing bones of the upper limb not only concerning the size of the bones but also the bone density and the biomechanical behavior of the bone. Materials & Methods: 59 male Wistar rats were used. The age of the aniimals was 3 weeks old. In all animals the roots of the left brachial plexus were dissected. The animals were separated into three major groups according to the denervation. In group A, the animals were sacrificed 6 months after denervation and both humerus underwent comparative biomachanic and histological examination. In group B thse examinations took place 9 months after denervation and in group C 12 months after denervation. Additionally, in group C there was a subgroup of animals which underwent micro-CT examination. Results: In group A, six months after denervation, the biomechanical study showed reduced maximum breaking force compared to the contralateral normal limb. Moreover, the displacement of the denervated bones was bigger before the fracture of the bone. On the other hand, there wre no differences between the normal and denervated bones I the histological study. The same results were noticed 9 months after denervation. In the experimental which was examined 12 months after denervation the biomechanical differences were even bigger between the normal and the denervated bones. In addition, the histologic examination revealed thinning of the cartilage as well as thinning and dilution of the bone trabeculae. In the micro-CT it was found diminished bone density of the trabecular site of the denervated humerus. Conclusion: The bone growth is a multifactorial procedure. The peripheral nervous system affects bone growth positively. Apart from the size it affects also the bone density as well as the biomechanical behavior of the bone.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Subject classification: Νευρικό σύστημα
Keywords: Περιφερικό νευρικό σύστημα,Οστική ανάπτυξη,Βραχιόνιο πλέγμα,Εμβιομηχανική,Οστική πυκνότητα,Peripheral nervous system,Bone growth,Brachial plexus,Biomechanics,Bone density
Appears in Collections:Διδακτορικές Διατριβές

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