Computational study of microfluidics and mechanical biosensors (suspended microcantilevers) (Master thesis)

Γαβαλάς, Ιάκωβος


In this work, a computational study of microfluidics and mechanical biosensors (suspended microcantilevers) is employed using the Finite Elements Method. The aim of this work is to fabricate a Lab-on-a-Chip (LoC) and a Point-of-Care (PoC) device to measure the dynamic viscosity of the Newtonian and Non-Newtonian fluids. This type of biosensors has shown extremely promising results and applications in the field of the biosensors. The current thesis is divided into 8 Chapters. In Chapter 1, a brief introduction to microfluidics is presented. The most important and useful for this work definitions are introduced. In Chapter 2, the origin, the types and the functionality of the biosensors are presented. In Chapter 3, a specific type of mechanical biosensors, the suspended microcantilever, is analyzed. In Chapter 4, the evolution in the field of the suspended microcantilevers, as well as the Finite Elements Method (FEM) simulation of them, is introduced. In Chapter 5, the different mechanical biosensors’ geometries that are used, the hypothesis, the equations and the boundary conditions of the problem are introduced. Chapter 6, is dedicated to the numerical solution of the current problem by employing FEM. In Chapter 7, the results of our experiments are presented. Finally, Chapter 8, summarizes the conclusions of the current work. The results of the simulations predict a highly sensitive biosensor comparing to previous published works. The proposed microcantilever was tested using Newtonian and Non-Newtonian fluids showing promising results. Finally, its small size is crucial for its integration into LoC and PoC devices.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Πολυτεχνική Σχολή. Τμήμα Μηχανικών Επιστήμης Υλικών
Subject classification: Microfluidics
Keywords: Microfluidics,Biosensors
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/29294
Appears in Collections:Διατριβές Μεταπτυχιακής Έρευνας (Masters)

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