Blood flow modelling in arteries with deformable walls (Doctoral thesis)

Σιόγκας, Παναγιώτης Κ.

This thesis deals with blood flow modelling in arteries with rigid or deformable walls. Its primary scope is to investigate the influence of the arterial wall on blood flow modelling and in particular, on important hemodynamic parameters such as intravascular pressures and wall shear stress. In this direction, finite element simulations are performed on patient-specific 3-dimensional coronary arterial models using real patient-specific boundary conditions in order to validate the efficacy of both methods (i.e. rigid or deformable walls). The subsequent scope of the thesis is to establish new computational methods for the functional assessment of coronary stenoses utilizing non-invasive or invasive coronary imaging modalities, with emphasis given on non-invasive techniques. The final aim of this thesis is to create integrated software suites of 3D reconstruction and functional assessment of coronary arteries that will aid the clinician in every day clinical practice. The main contributions of this thesis can be summarized as: (i) the validation of the accuracy of blood flow simulations regarding important hemodynamic factors such as intravascular pressures, (ii) the thorough comparison between blood flow simulations in coronary arteries using rigid or deformable arterial walls, (iii) the application and establishment of indices (i.e. vFAI and smartFFR) for the functional assessment of coronary stenoses using either non-invasive (i.e. CCTA) or invasive coronary imaging modalities (i.e. IVUS or IVUS-ICA fusion), (iv) their comparison to already established techniques such as FFR and stress MBF and (v) the development of integrated systems for 3D coronary reconstruction, functional assessment and multiscale modelling.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Πολυτεχνική Σχολή. Τμήμα Μηχανικών Επιστήμης Υλικών
Subject classification: Modelling
Keywords: Μοντελοποίηση,Ροή αίματος,Καρδιαγγειακές παθήσεις,Τμηματική εφεδρεία ροής,Αρτηριακό τοίχωμα,Modelling,Blood flow,Cardiovascular diseases,Fractional flow reserve,Arterial wall
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