The impact of metabolic syndrome and its components on perioperative outcomes after elective laparotomy (Doctoral thesis)

Λαού, Ελένη Γ.


Metabolic syndrome (MetS) comprises a constellation of risk factors that include high blood pressure, atherogenic dyslipidaemia, elevated fasting blood glucose and central obesity. MetS is frequent in the general population and has been associated with several comorbidities. The aim of this study was to access the impact of MetS on perioperative outcomes of patients undergoing elective abdominal surgery via laparotomy.METHODS: This prospective observational study (ClinicalTrials.gov:NCT02447523) invcluded 105 consecutive not known-diabetic patients (ASA I-III) undergoing elective abdominal surgery via laparotomy. Patients were divided into two groups based on the established diagnosis of MetS. Clinical characteristics, intra- and post-operative data, laboratory measurements and perioperative adverse events according to the European Perioperative Clinical Outcome (EPCO) definitions were recorded.RESULTS: The prevalence of MetS was 57.1%. Coronary artery disease and peripheral vascular disease were more prevalent in MetS patients (p<0.05). Operative data (duration of surgery and anaesthesia, volume of crystalloids and colloids given) were similar among groups. The presence of MetS was associated with a 2.64 higher odds (95% CI 1.18-5.95, p=0.019) for respiratory events and a 3.42 higher odds (95% CI 1.05-11.13, p=0.041) for superficial surgical site infections. . Furthermore, regarding MetS patients, all individual components of MetS were associated with worse outcomes in an independent manner.CONCLUSION: In our study, MetS and its individual components were associated with an increased risk of perioperative events in patients undergoing elective abdominal surgery via laparotomy.
Institution and School/Department of submitter: Πανεπιστήμιο Ιωαννίνων. Σχολή Επιστημών Υγείας. Τμήμα Ιατρικής
Subject classification: Μεταβολικό σύνδρομο
Keywords: Μεταβολικό σύνδρομο,Επίδραση,Εκλεκτική λαπαροτομία,Περιεγχειρητική έκβαση,Αναισθησία,Metabolic syndrome,Impact,Elective laparotomy,Perioperative outcome,Anesthesia
URI: http://olympias.lib.uoi.gr/jspui/handle/123456789/29209
Appears in Collections:Διδακτορικές Διατριβές

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